Summary
In a series of five patients severe untoward effects were noted in two patients, including one death which the writers attributed to the antabuse-alcohol combination. These tests indicate caution in the use of antabuse. A second series of clinical trials indicates that small initial doses of alcohol are safer and can produce adequate reactions.
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References
Hald, Jacobsen and Larsen: The sensitizing effect of tetraethylthiuramidisulphide (antabuse) to ethyl alcohol. Acta Pharmacol., 4:285–296, 1948.
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Martinsen-Larsen, O., (extract): Nye Linier i Alkoholistbehandlingen. Ugeskrift for Laeger, 110:1207, 1948.
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Read at the Upstate Interhospital- Conference of the New York State Department of Mental Hygiene, at Syracuse, April 18, 1950.
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Steckler, P.P., Harris, L. A preliminary report on antabuse therapy for alcoholism. Psych Quar 25, 91–96 (1951). https://doi.org/10.1007/BF01584266
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DOI: https://doi.org/10.1007/BF01584266