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Application of chlorotrimethylsilane in Pictet–Spengler reaction

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Abstract

Chlorotrimethylsilane has been found to be an efficient condensing agent in the Pictet–Spengler reaction, affording an extremely straightforward synthetic route to tetrahydro-β-carboline derivatives and their analogs. The applicability of the method has been studied, and a representative library of structurally diverse products has been created.

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Acknowledgments

The authors thank Mr. Vitaliy V. Polovinko for NMR measurements and Mrs. Olga V. Manoylenko for chromatographic separations.

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Correspondence to Sergey V. Ryabukhin.

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706_2012_804_MOESM1_ESM.doc

Supporting Information Compound data for all known compounds synthesized, 1H NMR, 13C NMR spectral data, APCI-MS data, and elemental analysis. This material is available free of charge via the internet. (DOC 118 kb)

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Ryabukhin, S.V., Panov, D.M., Plaskon, A.S. et al. Application of chlorotrimethylsilane in Pictet–Spengler reaction. Monatsh Chem 143, 1507–1517 (2012). https://doi.org/10.1007/s00706-012-0804-7

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  • DOI: https://doi.org/10.1007/s00706-012-0804-7

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