Clinical ResearchVascular DiseaseTadalafil for the Treatment of Pulmonary Arterial Hypertension: A Double-Blind 52-Week Uncontrolled Extension Study
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This study was supported by Eli Lilly & Company. A licensing agreement exists between Eli Lilly and United Therapeutics. Dr. Oudiz has received consulting and speaking fees, honoraria, and research support from Actelion, Bayer, Gilead, Eli Lilly & Company, Lung LLC, Medtronic, Novartis, Pfizer, and United Therapeutics. Dr. Brundage has chaired or been a member of data monitoring committees for clinical trials involving patients with pulmonary arterial hypertension for Actelion, Gilead, Novartis, Pfizer, Lung Rx, GlaxoSmithKline, and United Therapeutics; and is a member of the End-Point Adjudication Committee for Novartis and Medtronic and the Scientific Advisory Committee for Eli Lilly & Company regarding the PHIRST-1 clinical trial. Dr. Galiè has been involved with steering committee activities for Eli Lilly & Company, Actelion, Pfizer, United Therapeutics, Bayer-Schering, and GlaxoSmithKline; has been a paid lecturer for Actelion, Pfizer, Bayer-Schering, and GlaxoSmithKline; and has done contract research for Eli Lilly & Company, Actelion, Pfizer, United Therapeutics, Bayer-Schering, and GlaxoSmithKline. Dr. Ghofrani has received honoraria from, acted as a consultant for, and/or been a steering committee member for Actelion, Bayer-Schering, Eli Lilly & Company, Ergonex, GlaxoSmithKline, Novartis, Pfizer, and United Therapeutics. Dr. Simonneau has received research support and/or acted as a consultant for Actelion, Bayer-Schering, GlaxoSmithKline, Pfizer, and United Therapeutics. Dr. Botros is an employee of and stockholder in Eli Lilly & Company. Ms. Chan is an employee of and stockholder in Eli Lilly & Company. Mr. Beardsworth is an employee of and stockholder in Eli Lilly & Company. Dr. Barst has received support for serving as a consultant and scientific advisor to Actelion, Bayer, Eli Lilly & Company, Gilead, Ikaria, Merck, Novartis, and Pfizer.