Chemical Industry and Chemical Engineering Quarterly 2011 Volume 17, Issue 2, Pages: 125-132
https://doi.org/10.2298/CICEQ100816062A
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Spectrophotometric determination of tadalafil in pure and dosage forms
Al Kaf Ali
Gouda Ayman A.
Two simple, rapid, and extractive spectrophotometric methods were developed
for the determination of tadalafil (TDF) in both pure and tablet dosage form.
These methods are based on the formation of ion-pair complexes between the
basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange
(MO) in acidic buffer solution. The formed complexes were extracted with
chloroform and measured at 410 and 425 nm using BCP and MO, respectively.
Beer’s law was obeyed in the range 2.0-20 μg mL−1 with correlation
coefficient (n = 6) ≥ 0.9996. The molar absorpitivity, Sandell sensitivity,
detection and quantification limits were also calculated. The composition of
the ion pairs was found 1:1 by Job’s method. The proposed methods have been
applied successfully for the analysis of TDF in pure and in its dosage forms.
These developed methods were validated for accuracy and precision.
Keywords: tadalafil, spectrophotometry, ion pair complex, bromocresol purple, methyl orange
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