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Response to treatment with tadalafil in men with erectile dysfunction who reported no successful intercourse attempts at baseline

International Journal of Impotence Research volume 20, pages 554–560 (2008)Cite this article

Abstract

The purpose of this post hoc analysis was to evaluate response to tadalafil in patients with erectile dysfunction (ED) who reported failures in all sexual intercourse attempts before treatment. In a multicenter, open-label study, 1911 men received tadalafil 20 mg dosed as needed (up to once daily), for 12 weeks following a 4-week treatment-free run-in period. Efficacy measures included the sexual encounter profile (SEP) and the erectile function (EF) domain of the International Index of Erectile Function (IIEF-EF). Approximately, one-half (n=952, 49.9%) of the patients reported no successful intercourse attempts during the 4-week run-in period. Of these, 771 patients (81.0%) had at least one successful intercourse attempt during the treatment period. Furthermore, among responders, mean IIEF-EF scores at study end were similar regardless of success or no success at baseline. Patients who are unable to have successful intercourse should be encouraged to try oral phosphodiesterase type 5 inhibitor treatment for ED.

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Acknowledgements

We thank Haoyue L Zeigler, MS and Jeffrey R Means, PhD, Eli Lilly and Company, for reviewing and commenting on the paper. Assistance with paper preparation was provided by Danette Hann, PhD, i3 Statprobe.

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Authors and Affiliations

  1. Division of Urology, Maimonides Medical Center and Columbia University, New York, NY, USA

    R Shabsigh

  2. University of Tennessee Graduate School of Medicine, Knoxville, TN, USA

    E D Kim

  3. New England Research Institute, Watertown, MA, USA

    R C Rosen

  4. Santa Clara Valley Medical Center, San Jose, CA, USA

    R Shinghal

  5. Eli Lilly and Company, Indianapolis, IN, USA

    F Natanegara, D Muram & D G Wong

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  1. R Shabsigh
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  2. E D Kim
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  6. D Muram
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  7. D G Wong
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Correspondence to R Shabsigh.

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Shabsigh, R., Kim, E., Rosen, R. et al. Response to treatment with tadalafil in men with erectile dysfunction who reported no successful intercourse attempts at baseline. Int J Impot Res 20, 554–560 (2008). https://doi.org/10.1038/ijir.2008.38

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  • DOI: https://doi.org/10.1038/ijir.2008.38

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