Abstract UENPS.378
Sildenafil treatment in newborns: Two case reports

https://doi.org/10.1016/j.earlhumdev.2008.09.394Get rights and content

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Background and aim

Sildenafil is phosphodiesterase-5 inhibitor. Inhibition of phosphodiesterase-5 leads to increased concentration of cyclic guanosine monophosphate locally thereby enhancing the cyclic guanosine monophosphate mediated relaxation of smooth muscles in pulmonary arterial wall. Sildenafil can reduce hyperoxia-induced lung injury in newborn.

Materials and methods

Authors describe 2 cases of sildenafil treatment in premature newborn.

Case 1

A premature girl 28 weeks and 920 g at birth was admitted to NICU. A severe RDS developed rapidly with hyaline membrane disease on X-ray picture and was treated with endotracheal intubation, mechanical ventilation and exogenous surfactant. The course was complicated with Acinetobacter baumanii pulmonary infection. Echocardiography proved pulmonary arterial hypertension needed treatment with inhaled nitric oxide for 5 days. The boy was then put on oral sildenafil. During several days the

Conclusions

Sildenafil treatment may be helpful both in cases of persistent pulmonary hypertension of newborn and in new form of BPD with pulmonary vascular hypertension and cor pulmonale.

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