Skip to main content

Advertisement

SpringerLink
Log in

In vivo confocal microscopy in hydroxychloroquine-induced keratopathy

  • Case Report
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

Vortex keratopathy, arising as a side effect of several medications, is characterized by golden-brown deposits in the cornea.

Methods

A 41-year-old woman treated for sarcoidosis with hydroxychloroquine therapy and suffering from vortex keratopathy was examined by in vivo confocal microscopy. Scans of both corneas were performed.

Results

By slit lamp examination, the left but not the right eye showed a golden-brown deposit throughout the cornea. In vivo confocal microscopy revealed the presence of highly reflective, dot-like intracellular inclusions concentrated in the basal epithelial layer. They were also detected within the anterior and posterior stroma, but not within the endothelium. In regions of the anterior stroma, devoid of inclusions, hyperreflective ramified keratocytes were observed, forming an extended interconnecting network.

Conclusion

In addition to the granular deposits, in vivo confocal microscopy revealed hyperreflective, possibly phagocytic keratocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Chakravarti S, Wu F, Vij N, Roberts L, Joyce S (2004) Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea. Invest Ophthalmol Vis Sci 45:3475–3484

    Article  PubMed  Google Scholar 

  2. Ciancaglini M, Carpineto P, Zuppardi E, Nubile M, Doronzo E, Mastropasqua L (2001) In vivo confocal microscopy of patients with amiodarone-induced keratopathy. Cornea 20:368–373

    Article  PubMed  CAS  Google Scholar 

  3. D’Amico DJ, Kenyon KR, Ruskin JN (1981) Amiodarone keratopathy: drug-induced lipid storage disease. Arch Ophthalmol 99:257–261

    PubMed  CAS  Google Scholar 

  4. Dua HS, Singh A, Gomes JA, Laibson PR, Donoso LA, Tyagi S (1996) Vortex or whorl formation of cultured human corneal epithelial cells induced by magnetic fields. Eye 10(Pt 4):447–450

    PubMed  Google Scholar 

  5. Hirst LW, Sanborn G, Green WR, Miller NR, Heath WD (1982) Amodiaquine ocular changes. Arch Ophthalmol 100:1300–1304

    PubMed  CAS  Google Scholar 

  6. Hollander DA, Aldave AJ (2004) Drug-induced corneal complications. Curr Opin Ophthalmol 15:541–548

    Article  PubMed  Google Scholar 

  7. Ingram DV, Jaggarao NS, Chamberlain DA (1982) Ocular changes resulting from therapy with amiodarone. Br J Ophthalmol 66:676–679

    PubMed  CAS  Google Scholar 

  8. Poole CA, Brookes NH, Clover GM (2003) Confocal imaging of the human keratocyte network using the vital dye 5-chloromethylfluorescein diacetate. Clin Exp Ophthalmol 31:147–154

    Article  Google Scholar 

  9. Pulhorn G, Thiel HJ (1976) [Ultrastructural aspects of chloroquin-keratopathy (author’s transl)]. Albrecht Von Graefe's Arch Klin Exp Ophthalmol 201:89–99

    Article  CAS  Google Scholar 

  10. Slowik C, Somodi S, von Gruben C, Richter A, Guthoff R (1997) [Detection of morphological corneal changes caused by chloroquine therapy using confocal in vivo microscopy]. Ophthalmologe 94:147–151

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Eye Clinic, 22 rue Alcide Jentzer, 1211, Geneva 14, Switzerland

    André Dosso

  2. Cell Biology Laboratory, 22 rue Alcide Jentzer, 1211, Geneva 14, Switzerland

    Elisabeth Rungger-Brändle

Authors
  1. André Dosso
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elisabeth Rungger-Brändle
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to André Dosso.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dosso, A., Rungger-Brändle, E. In vivo confocal microscopy in hydroxychloroquine-induced keratopathy. Graefe's Arch Clin Exp Ophthalmol 245, 318–320 (2007). https://doi.org/10.1007/s00417-006-0365-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-006-0365-8

Keywords

Search

Navigation