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Epistaxis after PDE-5 inhibitors misuse

Abstract

A 32-year-old male presented to our department for recurrent epistaxis during sexual intercourses. The patient controlled the bleeding each time with sponge packs and gauzes. During the consultation, he volunteered that the trigger for the epistaxis appeared to have been misuse of phosphodiesterase (PDE)-5 inhibitors, Viagra and Cialis. This first report of epistaxis after PDE-5 inhibitors in a young patient underline the possibility that in the next years the number of similar cases might increase due to the diffusion of PDE-5 inhibitor misuse in recreational settings.

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References

  1. Middleton PM . Epistaxis. Emerg Med Australas 2004; 16: 428–440.

    PubMed  Google Scholar 

  2. Setter SM, Iltz JL, Fincham JE, Campbell RK, Baker DE . Phosphodiesterase 5 inhibitors for erectile dysfunction. Ann Pharmacother 2005; 39(7): 1286–1295.

    Article  CAS  Google Scholar 

  3. Smith KM, Romanelli F . Recreational use and misuse of phosphodiesterase 5 inhibitors. J Am Pharm Assoc (Wash DC) 2005; 45(1): 63–72.

    Article  Google Scholar 

  4. Ng BA, Ramsey RG, Corey JP . The distribution of nasal erectile mucosa as visualized by magnetic resonance imaging. Ear Nose Throat J 1999; 78: 159, 163–166.

    CAS  PubMed  Google Scholar 

  5. Hicklin LA, Ryan C, Wong DK, Hinton AE . Nose-bleeds after sildenafil (Viagra). J R Soc Med 2002; 95(8): 402–403.

    Article  CAS  Google Scholar 

  6. Berkels R, Klotz T, Sticht G, Englemann U, Klaus W . Modulation of human platelet aggregation by the phosphodiesterase type 5 inhibitor sildenafil. J Cardiovasc Pharmacol 2001; 37: 413–421.

    Article  CAS  Google Scholar 

  7. Bott SR, Shergill I, Arya M . Epistaxis after sildenafil. J R Soc Med 2002; 95: 528.

    Article  Google Scholar 

  8. Tzathas C, Christidou A, Ladas SD . Sildenafil (viagra) is a risk factor for acute variceal bleeding. Am J Gastroenterol 2002; 97: 1856.

    Article  Google Scholar 

  9. Monteseirin J, Camacho MJ, Bonilla I, Sanchez-Hernandez C, Hernandez M, Conde J . Honeymoon rhinitis. Allergy 2001; 56(4): 353–354.

    Article  CAS  Google Scholar 

  10. Ismail H, Harries PG . Recurrent epistaxis after treatment with tadalafil (Cialis). Acta Otolaryngol 2005; 125: 334–335.

    Article  CAS  Google Scholar 

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Correspondence to G Pomara.

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Pomara, G., Morelli, G., Menchini-Fabris, F. et al. Epistaxis after PDE-5 inhibitors misuse. Int J Impot Res 18, 213–214 (2006). https://doi.org/10.1038/sj.ijir.3901383

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  • DOI: https://doi.org/10.1038/sj.ijir.3901383

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