Abstract
The dose-dependency and time-course of the short-term visual effects of sildenafil citrate (VIAGRA®) were tested in two subjects. Blood pressure was measured and samples of blood taken at 30 min intervals before and after drug administration. In the first experiment, prolongations of the implicit times of the scotopic maximum a-wave, cone a- and b-wave, 33 Hz flicker, ON-response a- and b-wave and 3.3 Hz a- and b-wave electroretinogram (ERG) recordings and of the oscillatory potentials OP1, OP2, and OP3 were observed for both eyes of both subjects, following 100 or 200 mg dosings. Interestingly, no prolongation was found for OP4, to which the OFF-bipolar cell pathway significantly contributes. In the second experiment, in which visual function was repeatedly assessed following a 200 mg dose, similar prolongations were found in both eyes of one subject for the implicit times of the oscillatory potential OP2, the cone b-wave response and the 3.3 Hz a-wave. Moreover, the steady-state (A0) and immediate extinction (B0) blue target thresholds of transient tritanopia were raised relative to the pre-drug administration baseline effects. While the maximum lowering of both systolic and diastolic blood pressure approximately correlated with the peak plasma concentration of sildenafil (c. 30–60 min after administration), the peak magnitudes of most visual effects were found at c. 110 min, consistent with a second compartment kinetic.
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References
H Jägle C Jägle L. Sèrey (2004) ArticleTitleVisual short-term effects of Viagra: double-blind study in healthy young subjects Am J Ophthalmol 137 842–9 Occurrence Handle15126148
MF Marmor GE Holder MW Seeliger S. Yamamoto (2004) ArticleTitleStandard for clinical electroretinography (2004 update) Doc Ophthalmol 108 107–14 Occurrence Handle10.1023/B:DOOP.0000036793.44912.45 Occurrence Handle15455793
JD Unadkat F Bartha LB Sheiner (1986) ArticleTitleSimultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models Clin Pharmacol Ther 40 86–93 Occurrence Handle3720181 Occurrence Handle1:CAS:528:DyaL28XkvFSkt70%3D Occurrence Handle10.1038/clpt.1986.143
L Wachtmeister (1981) ArticleTitleFurther studies of the chemical sensitivity of the oscillatory potentials of the electroretinogram (ERG). II. Glutamate–aspartate- and dopamine antagonists Acta Ophthalmol (Copenh) 59 247–58 Occurrence Handle1:CAS:528:DyaL3MXksF2jtLc%3D
L. Wachtmeister (1981) ArticleTitleFurther studies of the chemical sensitivity of the oscillatory potentials of the electroretinogram (ERG). III. Some omega amino acids and ethanol Acta Ophthalmol (Copenh) 59 609–19 Occurrence Handle1:CAS:528:DyaL3MXmtFGnsbk%3D
JR Heckenlively DA Martin AL. Rosenbaum (1983) ArticleTitleLoss of electroretinographic oscillatory potentials, optic atrophy, and dysplasia in congenital stationary night blindness Am J Ophthalmol 96 526–34 Occurrence Handle6605090 Occurrence Handle1:STN:280:DyaL2c%2FitFWqtQ%3D%3D
P Lachapelle S Rousseau M McKerral (1998) ArticleTitleEvidence supportive of a functional discrimination between photopic oscillatory potentials as revealed with cone and rod mediated retinopathies Doc Ophthalmol 95 35–54 Occurrence Handle10.1023/A:1001784614333 Occurrence Handle10189180 Occurrence Handle1:STN:280:DyaK1M3gtlSlsQ%3D%3D
M Kojima E Zrenner (1978) ArticleTitleOff-components in response to brief light flashes in the oscillatory potential of the human electroretinogram Albrecht Von Graefes Arch Klin Exp Ophthalmol 206 107–20 Occurrence Handle10.1007/BF00414619 Occurrence Handle306772 Occurrence Handle1:STN:280:DyaE1c7osV2msA%3D%3D
H Heynen L Wachtmeister D Norren Particlevan (1985) ArticleTitleOrigin of the oscillatory potentials in the primate retina Vision Res 25 1365–73 Occurrence Handle4090272 Occurrence Handle1:STN:280:DyaL287isVOhtQ%3D%3D
WA Hare H. Ton (2002) ArticleTitleEffects of APB, PDA, and TTX on ERG responses recorded using both multifocal and conventional methods in monkey. Effects of APB, PDA, and TTX on monkey ERG responses Doc Ophthalmol 105 189–222 Occurrence Handle10.1023/A:1020553020264 Occurrence Handle12462444
CB Gabrieli F Regine EM Vingolo E Rispoli A. Isidori (2003) ArticleTitleAcute electroretinographic changes during sildenafil (Viagra) treatment for erectile dysfunction Doc Ophthalmol 107 111–14 Occurrence Handle10.1023/A:1026271404384
JK Luu AV Chappelow TJ McCulley MF. Marmor (2001) ArticleTitleAcute effects of sildenafil on the electroretinogram and multifocal electroretinogram Am J Ophthalmol 132 388–94 Occurrence Handle10.1016/S0002-9394(01)01052-2 Occurrence Handle11530053 Occurrence Handle1:CAS:528:DC%2BD3MXmt1Krtr0%3D
DC Hood W Seiple K Holopigian V. Greenstein (1997) ArticleTitleA comparison of the components of the multifocal and full-field ERGs Vis Neurosci 14 533–44 Occurrence Handle9194320 Occurrence Handle1:STN:280:DyaK2szjslGrsg%3D%3D Occurrence Handle10.1017/S0952523800012190
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Jägle, H., Jägle, C., Sèrey, L. et al. Dose-dependency and Time-course of Electrophysiologic Short-term Effects of VIAGRA®: A Case Study. Doc Ophthalmol 110, 247–254 (2005). https://doi.org/10.1007/s10633-005-0653-3
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DOI: https://doi.org/10.1007/s10633-005-0653-3