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Viagra: now mending hearts

Nature Medicine volume 11, pages 115–116 (2005)Cite this article

Viagra operates by increasing the levels of cGMP in target cells. This same mechanism underlies a newly discovered action of the drug in mouse hearts: counteracting hypertrophy (pages 214–222).

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Figure 1: Sildenafil, PKG-1 and hypertrophy.

Ann Thomson

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  1. Molecular Cardiology Research Institute, Tufts–New England Medical Center, Boston, 02111, Massachusetts, USA

    Michael E Mendelsohn

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  1. Michael E Mendelsohn
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Mendelsohn, M. Viagra: now mending hearts. Nat Med 11, 115–116 (2005). https://doi.org/10.1038/nm0205-115

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