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Sildenafil citrate significantly improves nocturnal penile erections in sildenafil non-responding patients with psychogenic erectile dysfunction

International Journal of Impotence Research volume 16, pages 552–556 (2004)Cite this article

Abstract

Effects of sildenafil citrate on nocturnal penile tumescence and rigidity (NPTR) were evaluated among sildenafil non-responding patients with psychogenic erectile dysfunction. All patients (n=30), equally divided into groups I and II, completed four consecutive nights using the RigiScan Plus device. Sildenafil citrate (50 mg) was given in the third night in group I and in the fourth in group II, whereas a placebo was given in the remaining nights. Additional patients (n=12) receiving only a placebo served as a control group. Results of NPTR recordings revealed neither significant differences between the control and non-sildenafil nights of both test groups, nor between the corresponding values of both groups (P>0.05). On the other hand, when sildenafil citrate nights of groups I and II taken together were compared with placebo nights, a significant increase of total events duration (P<0.001), average rigidity of the tip (P<0.05) and base (P<0.01), and rigidity activity unit (RAU) and tumescence activity unit (TAU) of tip and base (P<0.001) was observed. These results suggest that performance anxiety may be responsible for failure of response during awakening.

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References

  1. Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998; 338: 1397–1404.

    Article  CAS  Google Scholar 

  2. Boolell M et al. Oral sildenafil: an orally active type 5 cyclic GMP specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996; 8: 47–52.

    CAS  Google Scholar 

  3. Burnett AL . Nitric oxide in the penis: physiology and pathophysiology. J Urol 1997; 157: 320–324.

    Article  CAS  Google Scholar 

  4. McMahon CG, Samali R, Johnson H . Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction. J Urol 2000; 164: 1192–1196.

    Article  CAS  Google Scholar 

  5. Rosen RC . Psychogenic erectile dysfunction. Classification and management. Urol Clin North Am 2001; 28: 269–278.

    Article  CAS  Google Scholar 

  6. Lizza EF, Rosen RC . Definition and classification of erectile dysfunction: report of the Nomenclature Committee of the International Society of Impotence Research. Int J Impot Res 1999; 11: 141–143.

    Article  CAS  Google Scholar 

  7. Basar MM, Atan A, Tekdogan UY . New concept parameters of RigiScan in differentiation of vascular erectile dysfunction: is it a useful test? Int J Urol 2001; 8: 686–691.

    Article  CAS  Google Scholar 

  8. Terradas C, Levalle O, Nagelberg A, Mormandi E . Sildenafil improves nocturnal penile erections in organic impotence. Int J Impot Res 2001; 13: 125–129.

    Article  CAS  Google Scholar 

  9. Montorsi F et al. Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study. Urology 2000; 56: 906–911.

    Article  CAS  Google Scholar 

  10. Yaman O, Tokath Z, Inal T, Anafarta K . Effect of sildenafil on nocturnal erections of potent men. Int J Impot Res 2003; 15: 117–121.

    Article  CAS  Google Scholar 

  11. Pagani E et al. Anxiety and high catecholamines do not impair pharmaco-induced erection of psychogenic erectile dysfunction patients. Int J Impot Res 2003; 15: 282–286.

    Article  CAS  Google Scholar 

  12. Hatzichristou DG et al. Penile tumescence and rigidity monitoring in healthy volunteers: reproducibility, evaluation of the effect of sexual intercourse. J Urol 1998; 5: 561–564.

    Google Scholar 

  13. Rochira V et al. Effects of sildenafil on NPT and rigidity in normal men: randomized, placebo controlled, crossover study. J Androl 2002; 23: 566–571.

    CAS  PubMed  Google Scholar 

  14. Eardley I, Ellis P, Boolell M, Wulff M . Onset and duration of action of sildenafil for the treatment of erectile dysfunction. Br J Clin Pharmacol 2002; 53: 61–65.

    Article  Google Scholar 

  15. Van Lankveld JJ, Van Den Hout MA, Spigt MG, Van Koeveringe GA . Cognitive changes predict continued recovery of erectile functioning versus relapse after discontinuation of sildenafil treatment for male erectile dysfunction. Psychosom Med 2003; 65: 709–718.

    Article  CAS  Google Scholar 

  16. Wagner G, Saenz de Tejada I . Fortnightly review, update on male erectile dysfunction. BMJ 1998; 316: 678–682.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt

    M B Abdel-Naser & A Imam

  2. Department of Dermatology, Hospital Dresden-Friedrichstadt, Dresden, Germany

    U Wollina

Authors
  1. M B Abdel-Naser
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  2. A Imam
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  3. U Wollina
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Correspondence to M B Abdel-Naser.

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Abdel-Naser, M., Imam, A. & Wollina, U. Sildenafil citrate significantly improves nocturnal penile erections in sildenafil non-responding patients with psychogenic erectile dysfunction. Int J Impot Res 16, 552–556 (2004). https://doi.org/10.1038/sj.ijir.3901245

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  • DOI: https://doi.org/10.1038/sj.ijir.3901245

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