Elsevier

The Lancet

Volume 361, Issue 9353, 18 January 2003, Pages 262-263
The Lancet

Correspondence
Sildenafil for lung fibrosis and pulmonary hypertension

https://doi.org/10.1016/S0140-6736(03)12300-8Get rights and content

Cited by (6)

  • Phosphodiesterase-5 inhibition: The molecular biology of erectile function and dysfunction

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    In this case, the nitroglycerin medication provides a nitric oxide agonist drive to blood vessels throughout the body, and concomitant inhibition of PDE5 could produce a life-threatening or fatal hypotensive event. Recent reports indicate that sildenafil shows promise in treatment of other maladies associated with vascular dysfunction; this includes pulmonary hypertension where the nitric oxide agonist production in the affected vessels is robust and, therefore, the PDE5 inhibitors can act effectively to elevate cGMP [8,84–88]. Studies in animal models also suggest a role for sildenafil in improved recovery from stroke [89,90] and blunting or reversal of cardiac hypertrophy [91].

  • Sildenafil: Emerging cardiovascular indications

    2004, Annals of Thoracic Surgery
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    In patients with congestive heart failure and erectile dysfunction, a recently published double-blind, placebo-controlled study showed that sildenafil was not only well tolerated and effective for erectile dysfunction but it also improved exercise capacity [59]. In addition to the classic primary pulmonary hypertension and pulmonary hypertension that results from cardiac disease, some benefit might also exist in pulmonary hypertension of relatively rare etiology [34, 60–71], or postoperative pulmonary hypertension, and difficult weaning problems in mechanical respiration [72–75]. The weaning of inhaled NO, which is often followed by a rebound phenomenon, might especially be an indication for sildenafil [73, 75].

  • Effect of sildenafil in primary pulmonary hypertension

    2007, Pakistan Journal of Medical Sciences
  • Idiopathic pulmonary fibrosis: A decade of progress

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