Abstract
The objective of the study was to conduct a retrospective audit of patients who presented with priapism in Western Australia during the years 1985–2000. We searched the records of the teaching hospitals in metropolitan Perth and those of the Keogh Institute for Medical Research for the diagnostic code for priapism. A total of 82 episodes of priapism in 63 patients occurred over this 16 year period. In all, 62 episodes occurred after intracavernosal injections (ICI) and 20 were due to other causes. Treatment of priapism included simple aspiration of blood, intracavernosal injection of α-adrenergic agents and surgical shunt procedures. Priapism occurring outside the setting of ICI was more likely to require surgery; seven of 20 episodes. After ICI therapy, eight of 62 episodes required shunts. The use of prostaglandin E1 as the drug of choice in ICI therapy in 1989 led to a fall in the incidence of ICI-induced priapism. Priapism is a major side effect of ICI therapy and an uncommon, although important, side effect of other conditions. The incidence of priapism has fallen with the introduction of prostaglandin E1 monotherapy as the favoured drug for ICI therapy of erectile failure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 8 print issues and online access
$259.00 per year
only $32.38 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Keoghane SR, Sullivan ME, Miller MA . The aetiology, pathogenesis and management of priapism. Br J Urol Int 2002; 90: 149–154.
Virag R . Intracavernous injection of papaverine for erectile failure. Lancet 1982; 2: 938.
Brindley GS . Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence. Br J Psychiatry 1983; 143: 332–337.
Hedlund H, Andersson KE . Contraction and relaxation induced by some prostanoids in isolated human penile erectile tissue and cavernous artery. J Urol 1985; 134: 1245–1250.
Adaikan PG et al. A comparison of some pharmacological actions of prostaglandin E1, 6-oxo-PGE1 and PGI2. Prostaglandins 1984; 27: 505–516.
Ishii N et al. Intracavernous injection of prostaglandin E1 for the treatment of erectile impotence. J Urol 1989; 141: 323–325.
Porst H . The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J Urol 1996; 155: 802–815.
Australian Bureau of Statistics. Year Book Australia. Commonwealth of Australia: Canberra, 1997–2002.
Kulmala RV, Lehtonen TA, Tammela TL . Priapism, its incidence and seasonal distribution in Finland. Scand J Urol Nephrol 1995; 29: 93–96.
Eland IA, van der Lei J, Stricker BH, Sturkenboom MJ . Incidence of priapism in the general population. Urology 2001; 57: 970–972.
Meinhardt W et al. Comparison of a mixture of papaverine, phentolamine and prostaglandin E1 with other intracavernous injections. Eur Urol 1994; 26: 319–321.
Nellans RE, Ellis LR, Kramer-Levien D . Pharmacological erection: diagnosis and treatment applications in 69 patients. J Urol 1987; 138: 52–54.
Lomas GM, Jarow JP . Risk factors for papaverine-induced priapism. J Urol 1992; 147: 1280–1281.
Jackson SC, Walker JS . Self-administered intraurethral chlorpromazine: an unusual cause of priapism. Am J Emerg Med 1991; 9: 171–175.
Gilman AG, Goodman LS, Rall TW, Murad F . The Pharmacological Basis of Therapeutics. MacMillan: New York, 1985.
Tekell JL, Smith EA, Silva JA . Prolonged erection associated with risperidone treatment. Am J Psychiatry 1995; 152: 1097.
Emes CE, Millson RC . Risperidone-induced priapism. Can J Psychiatry 1994; 39: 315–316.
Welford C, Spies SM, Green D . Priapism in primary thrombocythemia. Arch Intern Med 1981; 141: 807–808.
Raven JL . Haemoglobinopathies in Australia. Med J Aust 1972; 2: 726–729.
Duggan ML, Morgan C Jr . Heparin: a cause of priapism? South Med J 1970; 63: 1131–1134.
De Siati M et al. Priapism as a complication of heparin therapy. Arch Ital Urol Androl 1999; 71: 201–202.
Burke BJ, Scott GL, Smith PJ, Wakerley GR . Heparin-associated priapism. Postgrad Med J 1983; 59: 332–333.
Klein LA, Hall RL, Smith RB . Surgical treatment of priapism: with a note on heparin-induced priapism. J Urol 1972; 108: 104–106.
Zimbelman J et al. Unusual complications of warfarin therapy: skin necrosis and priapism. J Pediatr 2000; 137: 266–268.
Routledge PA, Shetty HG, White JP, Collins P . Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant-associated priapism. Br J Clin Pharmacol 1998; 46: 343–346.
Salerno TA, Charrette EJ, Morales A . Priapism after aortic valve replacement. Can J Surg 1981; 24: 202–203.
Brindley GS . New treatment for priapism. Lancet 1984; 2: 220–221.
Lue TF, Hellstrom WJ, McAninch JW, Tanagho EA . Priapism: a refined approach to diagnosis and treatment. J Urol 1986; 136: 104–108.
Zorgniotti AW, Lefleur RS . Auto-injection of the corpus cavernosum with a vasoactive drug combination for vasculogenic impotence. J Urol 1985; 133: 3941.
Muruve N, Hosking DH . Intracorporeal phenylephrine in the treatment of priapism. J Urol 1996; 155: 141–143.
Jara J, Moncada I, Bueno G, Hernandez C . Intracavernous methoxamine in the treatment of priapism. Int J Impot Res 1998; 10: 257–259.
Sayer J, Parsons CL . Successful treatment of priapism with intracorporeal epinephrine. J Urol 1988; 140: 827.
van Driel MF, Joosten EA, Mensink HJ . Intracorporeal self-injection with epinephrine as treatment for idiopathic recurrent priapism. Eur Urol 1990; 17: 95–96.
Levine JF, Saenz de Tejada I, Payton TR, Goldstein I . Recurrent prolonged erections and priapism as a sequela of priapism: pathophysiology and management. J Urol 1991; 145: 764–767.
deHoll JD, Shin PA, Angle JF, Steers WD . Alternative approaches to the management of priapism. Int J Impot Res 1998; 10: 11–14.
Siegel JF, Reda E . Intracorporeal phenylephrine reduces thioridazine (Mellaril) induced priapism in a child. J Urol 1997; 157: 648.
Kulmala RV, Tamella TL . Effects of priapism lasting 24 hours or longer caused by intracavernosal injection of vasoactive drugs. Int J Impot Res 1995; 7: 131–136.
Acknowledgements
We thank Dr Ian Hill, Fremantle Hospital, Fremantle and Dr Antony Low (in memoriam), Royal Perth Hospital, Perth, Western Australia, Australia for their assistance with Ethics Committee submissions. We thank Alexander Stuckey for the statistical analysis and Lynley Ward for her assistance with graphics.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Earle, C., Stuckey, B., Ching, H. et al. The incidence and management of priapism in Western Australia: a 16 year audit. Int J Impot Res 15, 272–276 (2003). https://doi.org/10.1038/sj.ijir.3901018
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijir.3901018
Keywords
This article is cited by
-
A population-based analysis of predictors of penile surgical intervention among inpatients with acute priapism
International Journal of Impotence Research (2023)
-
Priapism: an Update on Principles and Practices
Current Sexual Health Reports (2014)
-
Incidence and clinical features of priapism in Japan: 46 cases from the Japanese diagnosis procedure combination database 2006–2008
International Journal of Impotence Research (2011)
-
A rare but significant cause of priapism in the elderly: multiple myeloma
Aging Clinical and Experimental Research (2011)
-
Evaluation and management of priapism: 2009 update
Nature Reviews Urology (2009)