Abstract
A patient with dysphagia and a history of breast cancer 11 yr ago was admitted to the hospital. A tumor presumably originating from the esophagus was detected. It could not be surgically removed and biopsy revealed adenocarcinoma. The patient received radiotherapy and chemotherapy consisting of etoposide, adriamycin, and cisplatin. An unexpectedly good response was achieved and the possibility of metastatic breast cancer was reinvestigated. Biopsy specimens showed positive estrogen and progesterone receptor staining. Tamoxifen treatment was started. The patient is well after 5 yr following relapse. Solitary esophageal metastasis of breast cancer is a rare event, especially after a remission period lasting more than a decade. Dysphagia in breast cancer patients should raise the suspicion of metastatic disease as well as esophageal cancer and benign strictures.
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Kadakia, S. C., Parker, A. and Canales, L. (1992). Metastatic tumors to the upper gastrointestinal tract: Endoscopic experience. Am. J. Gastroenterol. 87:1418–1423.
Taal, B. G., den Hartog Jager, F. C. A., Steinmetz, R. and Peterse, H. (1992). The spectrum of gastrointestinal metastases of breast carcinoma: I. Stomach. Gastrointest. Endosc. 38:130–135.
Beaver, B. L., Denning, D. A. and Minton, J. P. (1986). Metastatic breast carcinoma of the gallbladder. J. Surg. Oncol. 31:240–242.
Franco, D., Martin, B., Smadja, C., Szekely, A. M. and Rougier, P. (1987). Biliary metastases of breast carcinoma. Cancer 60:96–99.
Taal, B. G., den Hartog Jager, F. C. A., Steinmetz, R. and Peterse, H. (1992). The spectrum of gastrointestinal metastases of breast carcinoma: II. The colon and rectum. Gastrointest. Endosc. 38:136–141.
Herrera, J. L. (1991). Benign and metastatic tumors of the esophagus. Gastroenterol. Clin. North Am. 20:775–789.
Phadke, M., Rao, U. and Takita, H. (1976). Metastatic tumors of esophagus. NY State J. Med. 76:963–965.
Eng, J., Pradham, G. N., Sabanathan, S. and Mearns, A. J. (1989). Malignant melanoma metastatic to the esophagus. Ann. Thorac. Surg. 48:287–288.
Givler, R. L. (1970). Esophageal lesions in leukemia and lymphoma. Am. J. Dig. Dis. 15:31–36.
Schottenfeld, D. and Berg, J. (1971). Incidence of multiple primary cancers: IV. Cancer of the female breast and genital organs. J. Natl. Cancer Inst. 46:161–170.
Perrier, G., Teniere, P., Graoc, Y., Scotte, M., Leblanc-Louvry, I. and Michot, F. (1998). Squamous cell carcinoma of the thoracic esophagus following radiation therapy for breast cancer. Hepato-Gastroenterology 45:2197–2201.
Goldberg, R. I., Rams, H., Stone, B. and Barkin, J. S. (1987). Dysphagia as the presenting symptom of recurrent breast carcinoma. Cancer 60:1085–1088.
Kochhar, R., Rajwanshi, A., Malik, A. K., Gupta, S. K. and Mehta, S. K. (1988). Endoscopic fine needle aspiration biopsy of gastroesophageal malignancies. Gastrointest. Endosc. 34:321–323.
Fiel, M. I., Cernaianu, G., Burstein, D. E. and Batheja, N. (1996). Value of GCDFP-15 (BRST-2) as a specific immunocytochemical marker for breast carcinoma in cytologic specimens. Acta Cytol. 40(4):637–641.
Mizobuchi, S., Tachimori, Y., Kato, H., Watanabe, H., Nakanishi, Y. and Ochiai A. (1997). Metastatic esophageal tumors from distant primary lesions: report of three esophagectomies and study of 1835 autopsy cases. Jpn. J. Clin. Oncol. 2:410–414.
Haim, N., Krugliak, P., Cohen, Y., Schwartzman, Z. and Benharroch, D. (1989). Esophageal metastasis from breast carcinoma associated with pseudoepitheliomatous hyperplasia: An unusual endoscopic diagnosis. J. Surg. Oncol. 41:278–281.
Fuiji, K., Nakanishi, Y., Ochiai, A., Tsuda, H., Yamaguchi, H., Tachimori, Y., et al. (1997). Solitary esophageal metastasis of breast cancer with 15 years’ latency: a case report and review of the literature. Pathol. Int. 47:614–617.
Stallone, R. J. and Roe, B. B. (1969). Breast carcinoma as a cause of dysphagia. Dis. Chest 56:449–451.
Wu, C. M., Hruban, R. H. and Fishman, E. K. (1998). Breast carcinoma metastatic to the esophagus. CT findings with pathologic correlation. Clin. Imaging 22:343–345.
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Erman, M., Karaoğlu, A., Öksüzoğlu, B. et al. Solitary esophageal metastasis of breast cancer after 11 years. Med Oncol 19, 171–175 (2002). https://doi.org/10.1385/MO:19:3:171
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DOI: https://doi.org/10.1385/MO:19:3:171