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Sildenafil and erectile dysfunction

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References

  1. NIH Consensus Conference. Impotence. J. Am. Med. Ass. 1993, 270: 83–90.

    Article  Google Scholar 

  2. Feldman H.A., Goldstein I., Hatzichristou D.G., Krane R.J., McKinlay J.B. Impotence and its medical and psychological correlates: results of the Massachusetts male aging study. J. Urol. 1994, 151: 54–61.

    CAS  PubMed  Google Scholar 

  3. Lugg J.A., Gonzales-Cadavid N.F., Rajfer J. The role of nitric oxide in erectile function. J. Androl. 1995, 16: 2–4.

    CAS  PubMed  Google Scholar 

  4. Fabbri A., Aversa A., Isidori A. Erectile dysfunction: an overview. Hum. Reprod. Update 1997, 3: 455–466.

    Article  CAS  PubMed  Google Scholar 

  5. Heaton J.P.W., Adams M.A., Morales A. A therapeutic taxonomy of treatments for erectile dysfunction: an evolutionary imperative. Int. J. Impot. Res. 1997, 9: 115–121.

    Article  CAS  PubMed  Google Scholar 

  6. Ballard S.A., Burslem F.M.F., Gingell C.J.C., Price M.E., Tang K., Turner L.A., Naylor A.M. In vitro profile of UK-92-480, an inhibitor of cyclic GMP-specific phosphodiesterase 5 for the treatment of male erectile dysfunction. J. Urol. 155 (Suppl.) 1996, 676A, (Abst) 1462.

    Google Scholar 

  7. Boolell M., Allen M.J., Ballard S.A., Gepi-Attee S., Muirhead G.J., Naylor A.M., Osterloh I.H., Gingell C. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor in the treatment of penile erectile dysfunction. Int. J. Impot. Res. 1996, 8: 47–52.

    CAS  PubMed  Google Scholar 

  8. Ballard S.A., Gingell C.J., Tang K., Turner L.A., Price M.E., Naylor A.M. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol. 1998, 159: 2164–2171.

    Article  CAS  PubMed  Google Scholar 

  9. Hultling C., Giuliano F., Quirk F., Peña B., Mishra A., Smith M., and The Sildenafil Study Group. Effect of sildenafil (Viagra) on quality of life in men with erectile dysfunction (ED) caused by traumatic spinal cord injury (SCI). Int. J. Impot. Res. 1998, 10 (Suppl. 3), 532.

    Google Scholar 

  10. Goldstein I., Lue T.F., Padma-Nathan H., Rosen R.C., Steers W.D., Wcker P.A. Oral Sildenafil in the treatment of erectile dysfunction. N. Engl. J. Med. 1998, 338: 1397–1404.

    Article  CAS  PubMed  Google Scholar 

  11. Morales A., Gingell C., Collins M., Wicker P.A., Osterloh I. Clinical safety of oral sildenafil citrate (Viagra™) in the treatment of erectile dysfunction. Int. J. Impot. Res. 1998, 10: 69–74.

    Article  CAS  PubMed  Google Scholar 

  12. Chuang A.T., Strauss J.D., Murphy R.A., Steers W.D. Sildenafil, a type-5 phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro. J. Urol. 1998, 160: 257–261.

    Article  CAS  PubMed  Google Scholar 

  13. Soderling S.H., Bayuga S.J., Beavo J.A. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 1998, 273: 15553–15558.

    Article  CAS  PubMed  Google Scholar 

  14. Stief C.G., Uckert S., Becker A.J., Truss M.C., Jonas U. The effect of the specific phosphodiesterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo. J. Urol. 1998, 159: 1390–1393.

    Article  CAS  PubMed  Google Scholar 

  15. Feenstra J., van Drie-Pierik R.J.H.M., Laclè C.F., Stricker B.H.Ch. Acute myocardial infarction associated with sildenafil. Lancet 1998, 352: 957–958.

    Article  CAS  PubMed  Google Scholar 

  16. Wagner G., Saenz de Tejada I. Update on male erectile dysfunction. Br. Med. J. 1998, 316: 678–682.

    Article  CAS  Google Scholar 

  17. Mills T.M., Reilly C.M., Lewis R.W. Androgens and penile erection: a review. J. Androl. 1996, 17: 633–638.

    CAS  PubMed  Google Scholar 

  18. Aversa A., Bertucci B., Bonifacio V., Isidori A., Fabbri A. Dynamic color-Doppler Sonography in male erectile dysfunction: re-dosing with phentolamine plus prostaglandin-E1 to maximize erectile response. In: Meuleman E., Lycklama à Nijeholt G., Vanderschueren D. (Eds.), The 8th World Meeting on Impotence Research, Amsterdam, The Netherlands. Monduzzi Editore, Bologna, 1998, p. 215–218.

    Google Scholar 

  19. Porst H. The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J. Urol. 1996, 155: 802–815.

    Article  CAS  PubMed  Google Scholar 

  20. Heaton J.P.W., Adams M.A., Morales A., Hassouna M., Brock G., Mc Gill U., Shao Sigh R., Lue T.F., El Rasnioly R. Apomorphine SL is effective in the treatment of non-organic erectile dysfunction: results of a multicenter trial. Int. J. Impot. Res. 1996, 8: 109, (Abs) #A64.

    Google Scholar 

  21. Becker A.J., Stief C.G., Machtens S., Schulteiss D., Hartmann U., Truss M.C., Jonas U. Oral phentolamine as treatment for erectile dysfunction. J. Urol. 1998, 159: 1214–1215.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to A. Fabbri M.D., PhD.

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Fabbri, A., Aversa, A. & Isidori, A. Sildenafil and erectile dysfunction. J Endocrinol Invest 22, 486–492 (1999). https://doi.org/10.1007/BF03343595

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