Skip to main content
SpringerLink
Log in

Effects of elements on blood pressure

  • Original Articles
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

This article presents a comprehensive review of all known elements involved in blood pressure control. Data source was by computerized literature searches. A total of 28 elements have been documented as being involved in blood pressure control. The individual elements react directly and indirectly in a variety of metabolic and structural activities known to participate in blood pressure regulation. Reports from both experimental animal and human subjects are presented. The role of certain elements in blood pressure control is controversial. Conversely, important established functions of dosage, absorption, storage, and excretion of individual elements are known and are described in relation to blood pressure control. Some elements are pressor, whereas others are depressor in action, and this article demonstrates the important role elements play in the control of blood pressure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. C. Wexler,Lab. Invest. 25, 60 (1971).

    PubMed  CAS  Google Scholar 

  2. V. A. Granadillo, J. E. Tahan, O. Salgado, L. E. Elejalde, B. Rodriguez-Iturbe, G. B. Romero, and R. A. Romero,Clica. Chimca. Acta. 233 (12), 47–59 (1995).

    Article  CAS  Google Scholar 

  3. C. J. Chen, Y. M. Hsueh, M.S. Lai, M. P. Shyu, S. Y. Chen, M. M. Wu, T. L. Kuo, and T. Y. Tai,Hypertension 25 (1), 53–60 (1995).

    PubMed  Google Scholar 

  4. B. Upshaw, Jr. and T. Clayborn, Jr.Sothern Med. J. 88, 892 (1995).

    Google Scholar 

  5. D. F. Bohr,Fed. Proc. 33, 127–132 (1974).

    PubMed  CAS  Google Scholar 

  6. H. M. Perry, Jr., S. J. Kopp, E. F. Perry, M. W. Erlanger,J. Toxicol. Environ. Health 28, 373 (1989).

    Article  PubMed  CAS  Google Scholar 

  7. G. R. Brenniman, W. H. Kojola, P. S. Levy, B. W. Carnow and T. Nametaka,Arch. Environ. Health 36, 28 (1981).

    PubMed  CAS  Google Scholar 

  8. H. A. Schroeder and W. H. Vinton, Jr.,Am. J. Physiol. 202, 515–518.

  9. H. Perry, Jr.,Ann. NY Acad. Sci. 30, 220–221, (1978).

    Google Scholar 

  10. L. Friberg, C. G. Elinder, T. Kjellstrom, and G. F. Nordberg,Cadmium & Health, CRC Press, Chicago IL, p. 11 (1985).

    Google Scholar 

  11. H. Perry, Jr., R. Masironi, and P. Miller, J.,Trace Element Exp. Med. 4, 109–128 (1991).

    Google Scholar 

  12. H. Perry, Jr., E. Perry, and M. Erlanger, Trace Subst. in Environ. Health8, 51–57 (1974).

    CAS  Google Scholar 

  13. K. Nomiyama, H. Nomiyama, S. Lui, Y. Ishimaru and M. Hirai,Ann. NY Acad. Sci. 676, 308–326 (1993).

    Article  PubMed  CAS  Google Scholar 

  14. H. M. Perry and S. I. Kopp,Sci. Total Environ. 26, 223–232 (1983).

    Article  PubMed  CAS  Google Scholar 

  15. D. M. Medeiros and L. K. Pellum,Bull. Environ. Contam. Toxicol. 32, 525–532 (1984).

    Article  PubMed  CAS  Google Scholar 

  16. H. A. Schroder, A. P. Nason and I. H. Tipton,J. Chronic Dis. 20, 769–790 (1967).

    Article  Google Scholar 

  17. V. Karlicek, D. Topolcan, T. Bilbova, J. Kott, J. Sova,Cas. Lek. Ces. 110, 32 (1971).

    Google Scholar 

  18. T. L. M. Syverson, T. K. Sbrong, G. B. Syverson, and J. Opstad,Scand. J. Lab. Invest. 36, 251–256 (1976).

    Article  Google Scholar 

  19. S. Inderaprasit, G. V. Alexander, H. C. Gonick,J. Chronic Dis. 27, 135 (1974).

    Article  Google Scholar 

  20. K. Ostergard,Lancet 1, 677–678 (1977).

    Article  Google Scholar 

  21. D. Beevers, B. Campbell, A. Goldberg, M. Moore, and V. Hawthorne,J. Lancet 2, 1222–1225 (1976).

    Article  CAS  Google Scholar 

  22. P. Wester,Acta. Med. Scand. 194, 505–512 (1973).

    PubMed  CAS  Google Scholar 

  23. N. W. Revis and A. R. Zinsmeister,Proc. Soc. Exp. Biol. Med. 167, 254–260 (1981).

    PubMed  CAS  Google Scholar 

  24. H. A. Schroeder and H. M. Perry,J. Lab. Clin. Med. 46, 416–422 (1955).

    PubMed  CAS  Google Scholar 

  25. P. Weldman, S. G. Massry, J. W. Coburn, et al.,Ann. Intern. Med. 76, 741–745 (1972).

    Google Scholar 

  26. D. A. McCarron, C. D. Morris, H. J. Henry, et al.,Science 224, 392 (1984).

    Article  Google Scholar 

  27. F. P. Cappuccio, A. Siani, and P. Strazzullo,J. Hypertens 7, 941–946 (1989).

    Article  PubMed  CAS  Google Scholar 

  28. J. M. Earll, N. A. Klurtman, and R. H. Moser,Ann. Int. Med. 64, 378–381 (1966).

    PubMed  CAS  Google Scholar 

  29. L. Lind, A. Hanni, A. Hvarfner, T. Pollare, S. Ljunghall, H. Lithell,Am. J. Hypertens.,7, 302–7 (1994).

    PubMed  CAS  Google Scholar 

  30. H. Tamura,J. Jpn. Nephrol. 29, 107–113 (1987).

    Google Scholar 

  31. H. Zhou, S. Fan, L. Zhou, Y. Ni, T. Huang, and Y. Shi,Am. J. Hypertens. 7, 363–7 (1994).

    PubMed  CAS  Google Scholar 

  32. L. M. Resnick,Cardiovasc. Rev. and Rep. 9, 1341–1350 (1982).

    Google Scholar 

  33. H. Bucher, G. Guyatta, R. Cook, R. Hatala, D. Cook, et al.,JAMA 275, 1113–1117 (1996).

    Article  PubMed  CAS  Google Scholar 

  34. L. Goodman and A. Gillmans, Water, salts, and ions, InThe Pharmacological Basis of Therapeutics, MacMillan, p. 600 (1943).

  35. D. F. Bohr,Science 139, 597 (1963).

    Article  PubMed  CAS  Google Scholar 

  36. E. W. Young, R. D. Bukowski, and D. A. McCarron,Proc. Soc. Exp. Biol. Med. 187, 123 (1988).

    PubMed  CAS  Google Scholar 

  37. A. Ayach,Metabolism 28, 1234–1238 (1979).

    Article  Google Scholar 

  38. D. McCarron, N. N. Yung, B. A. Ugoretz, and S. Krutzik,Hypertension 2, 162–167 (1981).

    Google Scholar 

  39. H. A. Schroeder,J. Chronic Dis. 14, 236 (1961).

    Article  PubMed  CAS  Google Scholar 

  40. H. A. Schroeder, A. P. Nason, and I. H. Tipton,J. Chronic Dis. 20, 769–790 (1967).

    Article  Google Scholar 

  41. D. Cushman and H. Cheung,Biochem. Biophys. Acta. 250, 261–265 (1971).

    PubMed  CAS  Google Scholar 

  42. Y. Morin and P. Daniel,J. Can. Med. Assoc. 97, 926–931 (1967).

    CAS  Google Scholar 

  43. V. Morvai, E. Szakmary, E. Tatrai, G. Ungvary, and G. Folly,Acta. Physiologica. Hungarica 81 (3), 253–61 (1993).

    PubMed  CAS  Google Scholar 

  44. M. Fields, R. Ferretti, J. Smith, and S. Reiser,Am. J. Clin. Nutr. 39, 289–295 (1984).

    PubMed  CAS  Google Scholar 

  45. Y. S. Bakhle and A. M. Reynard,Nature New Biol. 229, 187–189 (1971).

    Article  PubMed  CAS  Google Scholar 

  46. F. E. Dorer, L. T. Skeggs, J. R. Khan, et al.,Anal. Biochem. 33, 102–113 (1970).

    Article  PubMed  CAS  Google Scholar 

  47. H. P. Schedl, M. L. Failla, and H. D. Wilson,Nutr. Res. 6, 1201–1209 (1986).

    Article  CAS  Google Scholar 

  48. H. F. Loyke,Biol. Trace Element Res. 29, 45–49 (1991).

    CAS  Google Scholar 

  49. M. J. Fregly, J. F. Gennaro, and A. B. Otis,Circ. Res 8, 749–758 (1960).

    PubMed  CAS  Google Scholar 

  50. M. J. Fregly,Am. J. Physiol. 194, 149 (1958).

    PubMed  CAS  Google Scholar 

  51. M. J. Fregly and C. L. Hood,Circ. Res. 7, 486 (1959).

    PubMed  CAS  Google Scholar 

  52. H. A. Schroeder,Circulation 35, 570–582 (1967).

    PubMed  CAS  Google Scholar 

  53. H. F. Loyke,Biol. Trace Element Res. 25, 47–50 (1990).

    CAS  Google Scholar 

  54. P. Samuels, E. K. Main, M. T. Mennuti, and S. G. Gabbe,Am. J. Obstet. Gynecol. 157, 721–725 (1987).

    PubMed  CAS  Google Scholar 

  55. S. Entman, L. Richardson and A. Killam,Am. J. Obstet. Gynecol. 143, 398–404 (1982).

    PubMed  CAS  Google Scholar 

  56. L. Goodman and A. Gillman, ed. R. S. Hilmam, C. A. Finch, Drugs Effective in Iron-Deficiency,The Pharmacological Basis of Therapeutics, MacMillan, p. 1310 (1985).

  57. W. Victery, A. Vander, J. Schoeps, and S. Julius,J. Lab. Clin. Med.,99, 354 (1982).

    PubMed  CAS  Google Scholar 

  58. H. F. Loyke,Bull. Environ. Contam. Toxicol. 34, (5), 730–735 (1985).

    Article  PubMed  CAS  Google Scholar 

  59. L. Neri and H. Johansen,Ann. NY Acad. Sci. 15, 203–221 (1978).

    Article  Google Scholar 

  60. J. L. Pirkle, J. Schwartz, J. R. Landis, and W. R. Harlan,Am. J. Epidemiol.,121, 246–258 (1985).

    PubMed  CAS  Google Scholar 

  61. V. Batuman, E. Landy, J. K. Maesaka, and R. P. Wedeen,N. Engl. J. Med.,309, 17–21 (1973).

    Google Scholar 

  62. I. Bach, S. Braun, T. Gati, et al.,Nature 192, 362–363 (1961).

    Article  PubMed  CAS  Google Scholar 

  63. H. E. Hansen and A. Amdisen,Q. J. Med. 47, 123–144 (1978).

    PubMed  CAS  Google Scholar 

  64. A. Kierkegaard-Haren,Acta. Pharmacol. Toxicol. 35, 370–378 (1974).

    Google Scholar 

  65. J. Michael, D. Ben-Ishay, et al.,JAMA 251, 1690 (1984).

    Article  Google Scholar 

  66. P. K. Zacharish and A. H. Rosenbaum,Mayo Clin. Proc. 57, 625–628 (1982).

    Google Scholar 

  67. B. M. Altura, B. T. Altura, A. Gebrewald, et al.,Science 223, 1315–1317 (1984).

    Article  PubMed  CAS  Google Scholar 

  68. A. K. Sangal and D. G. Beevers,Lancet 2, 498, (1982).

    Google Scholar 

  69. M. L. McCall and D. Sass,Am. J. Obstet. Gynecol. 71, 1089 (1956).

    PubMed  CAS  Google Scholar 

  70. L. M. Resnick, J. P. Nicholson, and J. H. Laragh,J. Cardiovasc. Pharmacol. 6, (1985).

    Google Scholar 

  71. T. Fujita, Y. Ito, H. Noda, and E. Ogata,Circulation 82, 384–393 (1990)

    PubMed  CAS  Google Scholar 

  72. C. P. Campanile, J. K. Crane, M. J. Peach, and J. C. Garrison,J. Biol. Chem. 257, 4951–4958 (1982).

    PubMed  CAS  Google Scholar 

  73. R. N. Stevenson, C. Keywood, A. Amadi, J. Davies, and D. Patterson,Heart 5,66, 19–21 (1991).

    Article  CAS  Google Scholar 

  74. F. Corica, R. Ientile, A. Allegra, G. Romano, et al.,Biol. Trace Element Res.,51, 13–21 (1996).

    Article  CAS  Google Scholar 

  75. J. C. Boyd and D. E. Burns,Clin. Chem. 29, 178 (1983).

    PubMed  CAS  Google Scholar 

  76. H. A. Schroeder,J. Chronic Dis. 18, 217–228 (1965).

    Article  PubMed  CAS  Google Scholar 

  77. H. M. Perry, Jr. and H. A. Schroder,J. Lab. Clin. Med. 46, 936 (1955).

    Google Scholar 

  78. L. S. Goodman, A. G. Gillman, and S. C. Harvey eds., Heavy metals, inThe Pharmacological Basis of Therapeutics, MacMillan, NY, p. 937 (1975).

    Google Scholar 

  79. A. M. Cirla, S. Costantini, A. B. Lemoxta,Med. Lavoro 61, 569–579 (1970).

    PubMed  CAS  Google Scholar 

  80. C. G. Huggins, R. J. Corcoran, J. S. Gordon, et al.,Circ. Res. (Suppl. I),27, (1970).

    CAS  Google Scholar 

  81. W. R. Harlan, A. L. Hill, R. P. Schmouder, et al., Dietary Intake & Cardiovascular Risk Factors, DHHS publication no. (PHS), Hyattsville, MD, p. 1676 (1983).

  82. H. G. Langford, J. C. Nainby-Luxemore, N. C. Nelson, et al.,Clin. Res. 28, 333A (1980).

    Google Scholar 

  83. E. I. Bloomguist, A. W. I. El-Bermarir, E. C. Yancey, and V. Karr-Dullion,Clin. Exp. Hyperten., (5), 447–453 (1983).

    Article  Google Scholar 

  84. R. J. M. Bindels, L. A. M. van den Broek, S. J. W. Hillebrand, and J. M. P. Wokke,Hypertension 9, 96–102 (1987).

    PubMed  CAS  Google Scholar 

  85. L. Tobian, J. Lange, K. Ulm, et al.,Hypertension (Suppl. I)7, (1985).

    Google Scholar 

  86. G. Krishna,J. Am. Soc. Nephrol. 1, 43–52 (1990).

    PubMed  CAS  Google Scholar 

  87. H. E. Jang, S. T. Grethe, T. Yuan-Chang, et al.,Hypertension 17, (3), 378–395 (1991).

    Google Scholar 

  88. R. L. Watson, H. G. Langford, J. D. Abernethy, et al.,Hypertension 2, (42), 93–98 (1980).

    PubMed  CAS  Google Scholar 

  89. G. Bunge,Textbook of Physiological & Pathological Chemistry, McGraw-Hill, NY, p. 73 (1902).

    Google Scholar 

  90. D. Santoro, A. Natali, C. Polumbo, et al.,Hypertension 28, 181–191 (1992).

    Google Scholar 

  91. Y. Gelinas and J. P. Schmit,Biometals 7, 155–162 (1994).

    Article  PubMed  CAS  Google Scholar 

  92. V. E. Lavine,Ann. NY Acad. Sci. 26, 385–394 (1915).

    Article  Google Scholar 

  93. F. Czapek and J. Weil,Arch. Exp. Pathol. Pharmacol. 32, 438–455 (1893).

    Article  Google Scholar 

  94. H. Perry, Jr., E. Perry, and M. Erlanger,Trace Substances in Environmental Health, D. D. Hemphill, ed., University of Missouri, Columbia, MO, p. 51 (1974).

    Google Scholar 

  95. H. D. Anderson and A. L. Moxon,J. Pharmacol. Exp. Ther. 76, 343–354 (1942).

    CAS  Google Scholar 

  96. C. O. Jones,Biochem. J. 4, 403–419 (1909).

    Google Scholar 

  97. M. A. Heinrich, Jr. and D. M. MacCanon,Toxicol. Appl. Pharmacol. 2, 33–43 (1960).

    Article  PubMed  CAS  Google Scholar 

  98. H. Hilse, P. Ochme, W. Krause and K. Aecht,Acta. Physiol. Pharmacol. Biol. 5, 47–50 (1979).

    CAS  Google Scholar 

  99. H. F. Loyke,Biol. Trace Element Res. 33, 129–133 (1992).

    Article  CAS  Google Scholar 

  100. T. A. Miettinen, G. Alfthan, J. K. Huttunen, et al.,Br. Med. J. 287, 517–519 (1983).

    CAS  Google Scholar 

  101. M. F. Robinson and C. S. Thomson,Nutrition Abstracts and Reviews—A 53, 3–26 (1983).

    Google Scholar 

  102. Y. Deguchi,Jpn. J. Hyg. 39, 924–929 (1985).

    CAS  Google Scholar 

  103. J. Tuomilehto,Prev. Med. 14, 413–427 (1985).

    Article  PubMed  CAS  Google Scholar 

  104. L. Ambard and E. Beaugard,Classics in Arterial Hypertension, Charles C. Thomas, Springfield, IL, p. 297 (1956).

    Google Scholar 

  105. L. A. Saperstein, W. L. Brandt, and D. R. Drury,Proc. Soc. Exp. Biol. Med. 73, 82–85 (1950).

    Google Scholar 

  106. G. Rose and J. Stamler,J. Hum. Hypertens..3, 283–288 (1989).

    PubMed  CAS  Google Scholar 

  107. G. MacGregor, E. Mervaala, H. Kappanen, et al.,Lancet 343, 545–546 (1994).

    Article  PubMed  CAS  Google Scholar 

  108. I. H. Page,Hypertension Mechanisms, Bruce Stratton, Orlando FL, p. 211 (1987).

    Google Scholar 

  109. M. Maxwell, A. U. Waks, and P. Orlando,Clinical Disorders of Fluids and Electrolyte Metabolism. W. B. Sanders, Philadelphia, PA, p. 869 (1987).

    Google Scholar 

  110. T. Kawasaki, C. S. Dlea, F. C. Bartter, et al.,Am. J. Med. 64, 193–198 (1978).

    Article  PubMed  CAS  Google Scholar 

  111. T. M. Morgan, R. Creed, and J. Hopper,Clin. Exp. Hypertens. Theory Prac. A8, 941–962 (1986).

    Article  Google Scholar 

  112. L. M. Resnick, J. H. Laragh, J. E. Sealey, et al.,N. Engl. J. Med. 309, 888–891 (1983).

    PubMed  CAS  Google Scholar 

  113. V. M. Campese, M. S. Romoff, D. Levitan, et al.,Kidney Int. 21, 371–378 (1982).

    Article  PubMed  CAS  Google Scholar 

  114. M. I. Koolen and P. V. VanBrummelen,Hypertension 6, 825–860 (1984).

    Google Scholar 

  115. J. P. Midgley, A. G. Matthew, C. M. Greenwood, and A. G. Logan,JAMA,275, 1590–1597 (1996).

    Article  PubMed  CAS  Google Scholar 

  116. W. J. Bank, D. E. Pleasure, K. Suzuki, M. Nigro, and R. Katz,Arch. Neurol. 26, 456–464 (1972).

    PubMed  CAS  Google Scholar 

  117. B. Escalante, D. Sacerdoti, M. M. Davidian, et al.,Hypertension 17, 776–779 (1991).

    PubMed  CAS  Google Scholar 

  118. J. Balassa and I. Tipton,J. Chronic Dis. 17, 483 (1964).

    Article  PubMed  Google Scholar 

  119. M. Laniado Schwartzman, N. B. Abraham, D. Sacerdoti, B. Escalante, J. C. McGiff, and J. Tohoku,J. Exp. Med.,166 (1), 85–91 (1992).

    CAS  Google Scholar 

  120. J. L. DaSalva, M. Tiefenthaler, E. Park, B. Escalante, M. L. Schwartzman, R. D. Levere, and N. G. Abraham,Am. J. Med. Sci. 307, (3), 173–181 (1994).

    Article  Google Scholar 

  121. P. Boscolo, M. Carmignani, A. R. Volpe, M. Felaco, G. DelRosso, G. Porcelli and G. Giuliano,Occup. Environ. Med. 51 (7), 500–3 (1994).

    Article  PubMed  CAS  Google Scholar 

  122. C. L. White, I. Jacob, H. Dahlenim, J. Pachorr, C. F. Mills, I. Bremner, J. K. Chester, eds. Fifth International Symposium on Trace Elements in Man and Animals, Farnham Royal Commonwealth Agricultural Bureau, p. 65 (1985).

  123. J. C. Schwartz, G. Gros, J. M. Lecomte, and J. Bralet,Life Sci. 47, 1279–1297 (1990).

    Article  PubMed  CAS  Google Scholar 

  124. G. Vivoli, M. Bergomi, R. Sergio, et al.,Zinc. Copper, and Zinc- or Copper-Dependent Enzymes in Hum. Hypertens. 49, 97–107 (1995).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Columbia Saint Vincent Charity Hospital, 2351 East 22 Street, 44115, Cleveland, OH

    Hubert F. Loyke

Authors
  1. Hubert F. Loyke
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Loyke, H.F. Effects of elements on blood pressure. Biol Trace Elem Res 58, 1–12 (1997). https://doi.org/10.1007/BF02910661

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02910661

Index Entries

Search

Navigation