Hydroxychloroquine treatment of rheumatoid arthritis

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Abstract

A variety of placebo-controlled and open studies have demonstrated the effectiveness of hydroxychloroquine in the treatment of rheumatoid arthritis. The excellent responses to recurrent treatment in a sample patient illustrate the value of hydroxychloroquine. Because low daily doses of hydroxychloroquine are associated with greater ophthalmologic safety, it would be advantageous to use the smallest effective daily dose, but there are no published controlled efficacy studies using daily doses of less than 400 mg. Hydroxychloroquine may best be employed to treat patients with new onset of disease or those in whom disease is not rapidly progressive. Great potential exists for the use of hydroxychloroquine in combination therapy, but optimal utilization of combination regimens will require performances of additional controlled studies.

References (17)

  • F Page

    Treatment of lupus erythematosus with mepacrine

    Lancet

    (1951)
  • EM Adams et al.

    Hydroxychloroquine in the treatment of rheumatoid arthritis

    Am J Med

    (1983)
  • GD Kersley et al.

    Amodiaquine and hydroxychloroquine in rheumatoid arthritis

    Lancet

    (1959)
  • AL Scherbel et al.

    Further observations on the use of 4-aminoquinoline compounds in patients with rheumatoid arthritis or related diseases

    Cleveland Clin Q

    (1958)
  • EBD Hamilton et al.

    Hydroxychloroquine sulfate (Plaquenil) in treatment of rheumatoid arthritis

    Arthritis Rheum

    (1962)
  • D Mainland et al.

    Hydroxychloroquine sulfate in rheumatoid arthritis, a six month, double-blind trial

    Bull Rheum Dis

    (1957)
  • JA Richter et al.

    Analysis of treatment termination with gold and antimalarial compounds in rheumatoid arthritis

    J Rheumatol

    (1980)
  • Z Husain et al.

    Treatment complications of rheumatoid arthritis with gold, hydroxychloroquine, D-penicillamine and levamisole

    J Rheumatol

    (1980)
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