Pustular psoriasis associated with hydroxychloroquine*

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  • Hydroxychloroquine effects on psoriasis: A systematic review and a cautionary note for COVID-19 treatment

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    In total, 15 studies met eligibility criteria and were used for data collection and analysis of 18 patients (Fig 1, Table I).14,16-29 The analysis of the level of evidence showed that 3 studies (20.0%) had a level of evidence of 4,19,26,27 and 12 studies (80.0%) had a level of evidence of 5.14,16-18,20-25,28,29 Overall, patients were aged between 25 and 71 years.

  • Characterizing the adverse dermatologic effects of hydroxychloroquine: A systematic review

    2020, Journal of the American Academy of Dermatology
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    After full-text review, studies that did not specify hydroxychloroquine as the cause of a particular adverse event were excluded (ie, Mittal2 2018). Study design, patient, and outcome data were extracted and summarized from each article (Table I).3-97 The search strategy revealed 1163 records after duplicates were removed.

  • Ixekizumab for treatment of refractory acute generalized exanthematous pustulosis caused by hydroxychloroquine

    2020, JAAD Case Reports
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    Because hydroxychloroquine is mainly excreted by the kidneys, renal impairment with a subsequently lower clearance of the drug may also have contributed to the continual symptoms in our patient. Rarely, antimalarial drugs have been reported to induce or exacerbate pustular psoriasis, and differentiating this disease from AGEP can be challenging.7 Together with the high AGEP validation score of the European Severe Cutaneous Adverse Reactions study group, the absence of a personal or family history of psoriasis and psoriasis arthritis, the lack of recurrence of pustular lesions at follow-up, and some histologic findings such as the presence of eosinophils and slight lichenoid inflammation support our diagnosis of AGEP.

  • Triggering psoriasis: the role of infections and medications

    2007, Clinics in Dermatology
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    Apart from their use in malaria, these drugs are also used for photosensitivity in systemic and discoid lupus erythematosus. Hydroxychloroquine and chloroquine have been reported to induce psoriasis and exacerbate existing psoriasis.87,88 The induction of psoriasis appears to be relatively rare compared with exacerbation of existing disease and has been questioned.89

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    2000, Clinics in Dermatology
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