This study examined the associations between lifestyle changes related to the COVID-19 pandemic, the psychological health of university students, and the potential moderating roles of dispositional mindfulness in these relationships. Participants (N=300) completed an online questionnaire survey assessing pre- and post-pandemic lifestyles and responded to psychological scales assessing stress, anxiety, depression, and mindfulness. The results indicated post-pandemic changes, including increased time spent at home, decreased time spent indoors, and increased self-reported frequency of exposure to COVID-19-related media reports. The increased time spent at home and indoors was significantly associated with higher stress and anxiety. Furthermore, there was a moderating effect of mindfulness, such that the frequency of post-pandemic exposure to media reports was less predictive of lower psychological health when mindfulness was relatively high. These results suggest that post-pandemic lifestyles and lifestyle changes influenced students’ psychological health compared to before the pandemic. Moreover, mindfulness played a protective role in this relationship.