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Trends in testosterone prescription amongst medical specialties: a 5-year CMS data analysis

Abstract

Testosterone Therapy (TTh) trends have changed as a result of clinical research and market forces over the past several years. Understanding the trends or preferences regarding testosterone prescriptions remains unknown. Our objective was to assess both regional and national trends in TTh prescriptions amongst medical specialties within the United States between 2013 and 2017. Publicly available data from the Center for Medicare and Medicaid Services (CMS) Part D Prescriber database with regards to TTh prescriptions across a 5-year span (January 1, 2013—December 31, 2017) were analyzed. TTh therapies were consolidated into four categories: Topical, Oral, Injection and Pellet. Statistical analysis utilizing R 4.0.2 was performed on the resulting data. Trends in prescription modality claim count and cost were plotted over the study period while statistical analysis evaluated associations between TTh modality and medical specialist. We found that Endocrinologists and Urologists prescribed topical testosterone more than all other specialties (60.4% and 53.5%, respectively), while Family and Internal medicine physicians were more likely to prescribe injections (59.82% and 50.69%, respectively). Oral and pellet testosterone were rarely prescribed across all specialties. In conclusion, the wide variation in modalities of testosterone prescriptions illustrates an opportunity for treatment guidelines to be streamlined across all specialists to improve patient outcomes.

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Fig. 1: Annual trends of testosterone claim counts across different medication forms.
Fig. 2: Five-year average of testosterone claim counts across the most prevalent specialties.
Fig. 3: Average testosterone claim count over 5 years across the most prevalent specialties.

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Authors and Affiliations

Authors

Contributions

Concept—MJC, TBC, TKJ, and NT. Design—TBC, TKJ, MJC, IVC, and WM. Supervision—NT, AM, and AM. Materials—AM, TBC, TKJ, and IVC. Data collection and/or processing—TKJ, TBC, and IVC. Analysis and/or interpretation—TKJ, TBC, IVC, AM, and WM. Literature search—MJC, IVC, and TBC. Writing paper—IVC, MJC, TBC, AM, and WM. Critical review—WM, AM, NT, and AL.

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Correspondence to Michael J. Callegari.

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Carter, I.V., Callegari, M.J., Jella, T.K. et al. Trends in testosterone prescription amongst medical specialties: a 5-year CMS data analysis. Int J Impot Res 35, 1–5 (2023). https://doi.org/10.1038/s41443-021-00497-6

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