TREATMENT DIRECTIONS OF ANEMIA AND IRON DEFICIENCY IN PATIENTS WITH CHRONIC HEART FAILURE

Khanyukov O. O., Pisotska L. A., Sapozhnychenko L. V., Pampukha O. O., Valchuk D. S.

LITERATURE REVIEWS

Scentific article

Abstract. Background. Anemia and iron deficiency are common comorbid conditions of patients with chronic heart failure (CHF). However, the issue of studying existing and developing new areas of treatment of anemia and iron deficiency in this category of patients still remains relevant. Aim. Review literature illustrating current data about treatment directions of anemia and iron deficiency in patients with CHF. Results. Treatment of anemia requires determination of its etiology and correction according to the cause, but a fairly common problem of establishing the etiology causes the complexity of subsequent treatment. Nowadays, the most reasonable approach to the treatment of iron deficiency and anemia for patients with CHF, taking into account current evidence (the results of randomized clinical trials) should be considered the intravenous use of iron carboxymaltose. In patients with CHF, treatment of severe anemia in the acute phase includes blood transfusion. The use of erythropoietin stimulants is not recommended for patients with CHF with anemia and/or iron deficiency. Oral iron therapy, which is often used as first-line therapy for iron deficiency for patients with CHF, does not have sufficient clinical data to support its efficacy. Promising areas that may be recommended after all the necessary clinical trials – the use of sugary iron, which is an innovative oral drug, drugs targeted to hepcidin. Conclusions. Patients with CHF, iron deficiency and anemia negatively affect functional ability, and are accompanied by an increase in hospitalizations and mortality. The development of new directions in the treatment of anemia and iron deficiency is becoming important in the context of treatment of patients with CHF, because the correction of these pathological conditions can reduce the clinical manifestations of CHF and improve the prognosis in this category of patients.

anemia, iron deficiency, chronic heart failure, treatment directions.

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«Bulletin of problems biology and medicine» Issue 4 (162), 2021 year, 70-76 pages, index UDK 616.12-008.46-036.1:616.155.194:612.393.4]-08

10.29254/2077-4214-2021-4-162-70-76