271
Citations
85
Journals
2013
First Cited
2021
Last Cited

Articles citing This Document (Page 3 of 6)

ArticleJournalYear
Reimagining the Framework Supporting the Static Analysis of Transporter Drug Interaction Risk; Integrated Use of Biomarkers to Generate Pan‐Transporter Inhibition Signatures
Assessment of drug–drug interaction potential with EDP ‐305, a farnesoid X receptor agonist, in healthy subjectsClinical and Translational Science
Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug-Drug and Drug-Disease Interactions of ApatinibFrontiers in Pharmacology2021
PET Imaging of ABC Transporters at the Blood-Brain Barrier2021
In Vitro/In Vivo Correlation for Drug-Drug Interactions2020
Effect of Food on the Pharmacokinetics of Gliclazide 60 mg Modified Release Tablet in Healthy Caucasian VolunteersActa Marisiensis - Seria Medica2018
Genomics and Drug Transporters and Application in Drug Discovery, Delivery, and Development2018
Some Methodologic Considerations in the Assessment of Methods for Predicting Pharmacokinetic Drug-Drug InteractionsClinical Pharmacology in Drug Development2017
Summary Report of Questionnaire Survey on Current Situation and Issues of Human Mass Balance Study Using Radioisotopes in JapanJapanese Journal of Clinical Pharmacology and Therapeutics2015
Evaluation of Time-Dependent CYP3A4 Inhibition Using Human HepatocytesMethods in Pharmacology and Toxicology2014
In Vitro Characterization of Intestinal Transporter, Breast Cancer Resistance Protein (BCRP)Methods in Pharmacology and Toxicology2014
In Vitro CYP Induction Using Human HepatocytesMethods in Pharmacology and Toxicology2014
In Vitro Characterization of Renal Transporters OAT1, OAT3, and OCT2Methods in Pharmacology and Toxicology2014
Membrane Transporters in ADMEAAPS Advances in the Pharmaceutical Sciences Series2013
In Vitro Kinetic Characterization of Transporter-Mediated PermeabilityAAPS Advances in the Pharmaceutical Sciences Series2013
Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug InteractionsClinical Pharmacology and Therapeutics2021
Drug-transporter interaction testing in drug discovery and developmentWorld Journal of Pharmacology2013
Irreversible enzyme inhibition kinetics and drug-drug interactionsMethods in Molecular Biology2014
Reversible mechanisms of enzyme inhibition and resulting clinical significanceMethods in Molecular Biology2014
Effect of Various Dosing Conditions on the Pharmacokinetics of Oral Semaglutide, a Human Glucagon-Like Peptide-1 Analogue in a Tablet FormulationDiabetes Therapy2021
Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical StudyClinical and Translational Science2021
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human HepatocytesClinical Pharmacology and Therapeutics2020
The Effects of Weak and Strong CYP3A Induction by Rifampicin on the Pharmacokinetics of Five Progestins and Ethinylestradiol Compared to MidazolamClinical Pharmacology and Therapeutics2020
Semimechanistic Modeling to Guide Venetoclax Coadministration with Ritonavir and DigoxinClinical and Translational Science2020
Test-Retest Repeatability of [F]MC225-PET in Rodents: A Tracer for Imaging of P-gp FunctionACS Chemical Neuroscience2020
Drug Interactions in the Liver2020
Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male SubjectsJournal of Clinical Pharmacology2020
Evaluation of absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitorXenobiotica2020
Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cellsBiochemical Pharmacology2020
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and CimetidineClinical Pharmacokinetics2020
Pharmacokinetic Drug Interactions of an Orally Available TRH Analog (Rovatirelin) With a CYP3A4/5 and P-Glycoprotein Inhibitor (Itraconazole)Journal of Clinical Pharmacology2020
Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activityJournal of Pharmacokinetics and Pharmacodynamics2020
Organic Cation Transporters in Human Physiology, Pharmacology, and ToxicologyInternational Journal of Molecular Sciences2020
Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentaryEuropean Journal of Pharmaceutics and Biopharmaceutics2020
Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous SuspensionAAPS Journal2020
Drug–Drug Interaction Studies2020
Assessment of Clinical Drug-Drug Interactions of Elagolix, a Gonadotropin-Releasing Hormone Receptor AntagonistJournal of Clinical Pharmacology2020
Ibrutinib does not have clinically relevant interactions with oral contraceptives or substrates of CYP3A and CYP2B6Pharmacology Research and Perspectives2020
Successful Extrapolation of Paracetamol Exposure from Adults to Infants After Oral Administration of a Pediatric Aqueous Suspension Is Highly Dependent on the Study Dosing ConditionsAAPS Journal2020
On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants: an Exploratory Study Highlighting the Importance of Infant FoodAAPS Journal2019
Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairmentXenobiotica2020
Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis for Caco-2 Cell Assay DataPharmaceutical Research2019
Effect of Food on the Pharmacokinetics of QuizartinibClinical Pharmacology in Drug Development2020
Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ modelXenobiotica2019
Absorption, disposition, metabolism and excretion of [C]mizagliflozin, a novel selective SGLT1 inhibitor, in ratsXenobiotica2019
Cardiovascular Risk Management and Hepatitis C: Combining DrugsClinical Pharmacokinetics2019
Assessment of CYP-Mediated Drug Interactions for Evocalcet, a New Calcimimetic Agent, Based on In Vitro Investigations and a Cocktail Study in HumansClinical and Translational Science2019
Management of Diabetes MellitusContemporary Cardiology2019
Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[C]Methylpurine in MiceMolecular Imaging and Biology2019
In Vitro Assessment of Potential for CYP-Inhibition-Based Drug-Drug Interaction Between Vonoprazan and ClopidogrelEuropean Journal of Drug Metabolism and Pharmacokinetics2019
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy SubjectsClinical Pharmacology in Drug Development2019
Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration RateClinical Pharmacology and Therapeutics2019
A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis DrugsClinical Pharmacokinetics2019
Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL reviewJournal of Pharmacy and Pharmacology2019
Evaluation of the Drug Interaction Potential of DoravirineAntimicrobial Agents and Chemotherapy2019
Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymesXenobiotica2019
Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy SubjectsClinical Pharmacokinetics2019
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrationsScientific Reports2019
Modulation of Fexofenadine Pharmacokinetics by Osimertinib in Patients With Advanced EGFR-Mutated Non-Small Cell Lung CancerJournal of Clinical Pharmacology2019
EASL Clinical Practice Guidelines: Drug-induced liver injuryJournal of Hepatology2019
Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy VolunteersClinical and Translational Science2019
Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced CholestasisMethods in Molecular Biology2019
A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and LocalizationClinical Pharmacology and Therapeutics2019
Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug-Drug Interaction Potential of Siponimod With Physiologically-Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label RecommendationsClinical Pharmacology and Therapeutics2019
Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva CocktailJournal of Personalized Medicine2019
Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cellsPLoS ONE2019
The association between polypharmacy and adverse health consequences in elderly type 2 diabetes mellitus patients; a systematic review and meta-analysisDiabetes Research and Clinical Practice2019
Physiologically-Based Pharmacokinetic Modeling Approach to Predict Rifampin-Mediated Intestinal P-Glycoprotein InductionCPT: Pharmacometrics and Systems Pharmacology2019
microRNA-206 modulates the hepatic expression of the organic anion-transporting polypeptide 1B1Liver International2019
A drug-drug interaction study to assess the potential effect of acid-reducing agent, lansoprazole, on quizartinib pharmacokineticsCancer Chemotherapy and Pharmacology2019
Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy SubjectsClinical Pharmacokinetics2019
Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products - a PEARRL reviewJournal of Pharmacy and Pharmacology2019
PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product LabelingClinical Pharmacology and Therapeutics2019
A randomized study investigating the effect of omeprazole on the pharmacokinetics of oral semaglutideExpert Opinion on Drug Metabolism and Toxicology2018
Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended ApproachDrug Metabolism and Disposition2018
Inhibition and stimulation of the human breast cancer resistance protein as in vitro predictor of drug-drug interactions of drugs of abuseArchives of Toxicology2018
In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector MachinesPharmaceutical Research2018
Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channelBiochemical Pharmacology2018
In Vitro/In Vivo Correlation for Drug-Drug Interactions2018
Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic ModelPharmaceutics2017
Drug–Drug Interaction Studies2018
Quantitative Prediction of OATP-Mediated Drug-Drug Interactions With Model-Based Analysis of Endogenous Biomarker KineticsCPT: Pharmacometrics and Systems Pharmacology2018
Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female SubjectsJournal of Clinical Pharmacology2018
Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsyBritish Journal of Clinical Pharmacology2018
Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activityExpert Opinion on Drug Metabolism and Toxicology2018
Sensitive and robust LC-MS/MS analysis of digoxin in human plasma through optimization of in-source adduct formationBioanalysis2018
Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case exampleBiopharmaceutics and Drug Disposition2018
A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug EvofosfamideCPT: Pharmacometrics and Systems Pharmacology2018
Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic AnalysisJournal of Clinical Pharmacology2018
Mass balance and metabolism of Z-215, a novel proton pump inhibitor, in healthy volunteersXenobiotica2018
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical modelsJournal of Applied Toxicology2018
In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid ReceptorClinical Pharmacology in Drug Development2018
Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or InducersPaediatric Drugs2018
In Vitro Comparison of the Role of P-Glycoprotein and Breast Cancer Resistance Protein on Direct Oral Anticoagulants DispositionEuropean Journal of Drug Metabolism and Pharmacokinetics2018
Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic ModellingBasic and Clinical Pharmacology and Toxicology2018
Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignanciesInvestigational New Drugs2018
A phase I study to assess the mass balance, excretion, and pharmacokinetics of [C]-ixazomib, an oral proteasome inhibitor, in patients with advanced solid tumorsInvestigational New Drugs2018
Organic Anion-Transporting Polypeptide (OATP)-Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized LiverDrug Metabolism and Disposition2018
In vitro drug-drug interactions of budesonide: inhibition and induction of transporters and cytochrome P450 enzymesXenobiotica2018
The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipagXenobiotica2018
Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter CocktailEuropean Journal of Drug Metabolism and Pharmacokinetics2018
Conflicting meal recommendations for oral oncology drugs: pose risks to patient care?European Journal of Clinical Pharmacology2018
Relationships of Changes in Pharmacokinetic Parameters of Substrate Drugs in Drug-Drug Interactions on Metabolizing Enzymes and TransportersJournal of Clinical Pharmacology2018
Characterization of the Pharmacokinetics of Vilaprisan: Bioavailability, Excretion, Biotransformation, and Drug-Drug Interaction PotentialClinical Pharmacokinetics2018
Reverse Translation of US Food and Drug Administration Reviews of Oncology New Molecular Entities Approved in 2011-2017: Lessons Learned for Anticancer Drug DevelopmentClinical and Translational Science2018
In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokineticsEuropean Journal of Clinical Pharmacology2018
Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugsBritish Journal of Clinical Pharmacology2018
Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug-Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition EffectsCPT: Pharmacometrics and Systems Pharmacology2018
Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant WomenCPT: Pharmacometrics and Systems Pharmacology2018
Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?Clinical Pharmacology and Therapeutics2018
Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactionsBritish Journal of Clinical Pharmacology2018
The Aspirin-NSAID Interaction: More Data, But a Lack of Clarity RemainsJournal of the American College of Cardiology2018
Development, Verification, and Prediction of Osimertinib Drug-Drug Interactions Using PBPK Modeling Approach to Inform Drug LabelCPT: Pharmacometrics and Systems Pharmacology2018
A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from natureScientific Reports2017
Role of ADME/PK in Drug Discovery, Safety Assessment, and Clinical Development2017
Importance of Publishing Adverse Drug Reaction Case Reports: Promoting Public Health and Advancing Pharmacology and TherapeuticsDrug Safety - Case Reports2017
Validation of a total IC method which enables in vitro assessment of transporter inhibition under semi-physiological conditionsXenobiotica2017
A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urineAnalytical and Bioanalytical Chemistry2017
CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosolFood Chemistry2017
Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug-drug interactions in rat liverXenobiotica2017
Caco-2 cells - expression, regulation and function of drug transporters compared with human jejunal tissueBiopharmaceutics and Drug Disposition2017
An exposure-response analysis based on rifampin suggests CYP3A4 induction is driven by AUC: an in vitro investigationXenobiotica2017
Preclinical evaluation of the potential for cytochrome P450 inhibition and induction of the selective ALK inhibitor, alectinibXenobiotica2017
Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication RegimensAAPS Journal2017
Physiologically based pharmacokinetic modeling in regulatory decision-making at the European Medicines AgencyClinical Pharmacology and Therapeutics2017
A pharmacokinetic drug-drug interaction study between selexipag and midazolam, a CYP3A4 substrate, in healthy male subjectsEuropean Journal of Clinical Pharmacology2017
The Ussing Chamber Assay to Study Drug Metabolism and Transport in the Human IntestineCurrent Protocols in Pharmacology2017
The conditional stimulation of rat organic cation transporter 2, but not its human ortholog, by mesoridazine: the possibility of the involvement of the high-affinity binding site of the transporter in the stimulationJournal of Pharmacy and Pharmacology2017
Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4Transplant Infectious Disease2017
An easy and fast adenosine 5'-diphosphate quantification procedure based on hydrophilic interaction liquid chromatography-high resolution tandem mass spectrometry for determination of the in vitro adenosine 5'-triphosphatase activity of the human breast cancer resistance protein ABCG2Journal of Chromatography A2017
Assessment of the Drug Interaction Potential of Unconjugated and GalNAc-Conjugated 2'-MOE-ASOsMolecular Therapy - Nucleic Acids2017
Pharmacovigilance: Work in ProgressPharmaceutical Medicine2017
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3AClinical Pharmacology and Therapeutics2017
Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of RosuvastatinDrug Metabolism and Disposition2017
Effects of Tenapanor on Cytochrome P450-Mediated Drug-Drug InteractionsClinical Pharmacology in Drug Development2017
Clinical Implications of P-Glycoprotein Modulation in Drug-Drug InteractionsDrugs2017
Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese VolunteersPharmaceutical Research2017
The Utility of a Population Approach in Drug-Drug Interaction Assessments: A Simulation EvaluationJournal of Clinical Pharmacology2017
The Role of the Kidney in Drug Elimination: Transport, Metabolism, and the Impact of Kidney Disease on Drug ClearanceClinical Pharmacology and Therapeutics2017
The Role of Drug Metabolites in the Inhibition of Cytochrome P450 EnzymesEuropean Journal of Drug Metabolism and Pharmacokinetics2017
Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEPJournal of Computer-Aided Molecular Design2017
Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington's diseaseBritish Journal of Clinical Pharmacology2017
Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In VitroDrug Metabolism and Disposition2017
Translational Research: Preclinical to Healthy Volunteer to PatientAAPS Advances in the Pharmaceutical Sciences Series2017
Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal RecipientsClinical Pharmacology and Therapeutics2017
Tenapanor administration and the activity of the H -coupled transporter PepT1 in healthy volunteersBritish Journal of Clinical Pharmacology2017
Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated TransportJournal of Pharmaceutical Sciences2017
Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy AdultsClinical Drug Investigation2017
A call for a consortium for optimal management of drug-drug interactions in patient careClinical Pharmacology and Therapeutics2017
Renal Drug Transporters and Drug InteractionsClinical Pharmacokinetics2017