| 1 | Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 574 |
| 2 | Mechanisms of Disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 511 |
| 3 | Thyroid hormone receptors in brain development and function | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 501 |
| 4 | The pathogenesis of diabetic nephropathy | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 458 |
| 5 | Pheochromocytoma: recommendations for clinical practice from the First International Symposium | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 426 |
| 6 | Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 363 |
| 7 | Clinical implications of a molecular genetic classification of monogenic β-cell diabetes | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 346 |
| 8 | Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 339 |
| 9 | Mechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 314 |
| 10 | Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1 | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 257 |
| 11 | Drug Insight: the role of leptin in human physiology and pathophysiology—emerging clinical applications | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 256 |
| 12 | Drug Insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 214 |
| 13 | Mechanisms of macrophage activation in obesity-induced insulin resistance | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 204 |
| 14 | The replication of β cells in normal physiology, in disease and for therapy | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 203 |
| 15 | Mechanisms of Disease: proatherogenic HDL—an evolving field | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 183 |
| 16 | The role of thyroid autoimmunity in fertility and pregnancy | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 182 |
| 17 | Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 174 |
| 18 | The prevention of type 2 diabetes | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 172 |
| 19 | Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 171 |
| 20 | The role of physical activity in producing and maintaining weight loss | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 169 |
| 21 | Mechanisms of Disease: the developmental origins of disease and the role of the epigenotype | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 158 |
| 22 | Biologic actions and therapeutic potential of the proglucagon-derived peptides | Nature Clinical Practice Endocrinology and Metabolism | 2005 | 155 |
| 23 | Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 153 |
| 24 | Mechanisms of Disease: pathway-selective insulin resistance and microvascular complications of diabetes | Nature Clinical Practice Endocrinology and Metabolism | 2005 | 140 |
| 25 | Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 139 |
| 26 | Thyroid-hormone therapy and thyroid cancer: a reassessment | Nature Clinical Practice Endocrinology and Metabolism | 2005 | 137 |
| 27 | Mechanisms of Disease: adipokines and breast cancer—endocrine and paracrine mechanisms that connect adiposity and breast cancer | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 133 |
| 28 | Clinical lessons from the calcium-sensing receptor | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 130 |
| 29 | Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 125 |
| 30 | The genetics of the polycystic ovary syndrome | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 121 |
| 31 | The role of the placenta in thyroid hormone delivery to the fetus | Nature Clinical Practice Endocrinology and Metabolism | 2009 | 119 |
| 32 | Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 117 |
| 33 | Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 116 |
| 34 | New therapeutic approaches to treat medullary thyroid carcinoma | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 114 |
| 35 | Technology Insight: in vitro culture of spermatogonial stem cells and their potential therapeutic uses | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 112 |
| 36 | Diabetic neuropathies: clinical manifestations and current treatment options | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 107 |
| 37 | Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 107 |
| 38 | A therapeutic strategy for incidentally detected papillary microcarcinoma of the thyroid | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 107 |
| 39 | Defects in iodide metabolism in thyroid cancer and implications for the follow-up and treatment of patients | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 99 |
| 40 | The metabolic syndrome in women | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 97 |
| 41 | Mechanisms of Disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 88 |
| 42 | Recognizing rare disorders: aromatase deficiency | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 86 |
| 43 | The reproductive phenotype in polycystic ovary syndrome | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 86 |
| 44 | Determination of calcitonin levels in C-cell disease: clinical interest and potential pitfalls | Nature Clinical Practice Endocrinology and Metabolism | 2009 | 85 |
| 45 | Radiation-induced hypopituitarism after cancer therapy: who, how and when to test | Nature Clinical Practice Endocrinology and Metabolism | 2009 | 85 |
| 46 | Clinical practice in Turner syndrome | Nature Clinical Practice Endocrinology and Metabolism | 2005 | 83 |
| 47 | Endocrine aspects of acute and prolonged critical illness | Nature Clinical Practice Endocrinology and Metabolism | 2006 | 82 |
| 48 | Surgical treatment of obesity | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 82 |
| 49 | Environmental factors and autoimmune thyroiditis | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 82 |
| 50 | Technology Insight: measuring thyroglobulin and thyroglobulin autoantibody in patients with differentiated thyroid cancer | Nature Clinical Practice Endocrinology and Metabolism | 2008 | 82 |