| 1 | Orphan drugs and rare diseases: a scientometric review (2000 – 2014) | Expert Opinion on Orphan Drugs | 2014 | 181 |
| 2 | Pseudoxanthoma elasticum: diagnostic features, classification and treatment options | Expert Opinion on Orphan Drugs | 2014 | 61 |
| 3 | Pathogenesis, emerging therapeutic targets and treatment in sialidosis | Expert Opinion on Orphan Drugs | 2015 | 59 |
| 4 | Diagnosis, prevalence, and screening of familial dilated cardiomyopathy | Expert Opinion on Orphan Drugs | 2015 | 55 |
| 5 | Leishmaniasis: treatment, drug resistance and emerging therapies | Expert Opinion on Orphan Drugs | 2019 | 50 |
| 6 | Machado Joseph disease: clinical and genetic aspects, and current treatment | Expert Opinion on Orphan Drugs | 2015 | 45 |
| 7 | Presentation and treatments for Mucopolysaccharidosis Type II (MPS II; Hunter Syndrome) | Expert Opinion on Orphan Drugs | 2017 | 45 |
| 8 | Gene therapy for the treatment of X-linked retinitis pigmentosa | Expert Opinion on Orphan Drugs | 2018 | 44 |
| 9 | Monitoring progression of retinitis pigmentosa: current recommendations and recent advances | Expert Opinion on Orphan Drugs | 2020 | 39 |
| 10 | Pathogenesis, epidemiology, diagnosis and clinical aspects of Smith–Lemli–Opitz syndrome | Expert Opinion on Orphan Drugs | 2015 | 38 |
| 11 | Pathogenesis, diagnosis and therapeutic strategies in WHIM syndrome immunodeficiency | Expert Opinion on Orphan Drugs | 2017 | 37 |
| 12 | The potential of utrophin modulators for the treatment of Duchenne muscular dystrophy | Expert Opinion on Orphan Drugs | 2018 | 37 |
| 13 | Alveolar echinococcosis: evaluation of therapeutic strategies | Expert Opinion on Orphan Drugs | 2014 | 34 |
| 14 | Pathogenic mechanisms and the prospect of gene therapy for choroideremia | Expert Opinion on Orphan Drugs | 2015 | 33 |
| 15 | Advances in understanding of Netherton syndrome and therapeutic implications | Expert Opinion on Orphan Drugs | 2020 | 33 |
| 16 | Current therapies for Morquio A syndrome and their clinical outcomes | Expert Opinion on Orphan Drugs | 2016 | 32 |
| 17 | Neurobiologically-based treatments in Rett syndrome: opportunities and challenges | Expert Opinion on Orphan Drugs | 2016 | 32 |
| 18 | Current and emerging therapies for the treatment of leishmaniasis | Expert Opinion on Orphan Drugs | 2024 | 32 |
| 19 | Galactosialidosis: historic aspects and overview of investigated and emerging treatment options | Expert Opinion on Orphan Drugs | 2017 | 31 |
| 20 | From mysteries to medicines: drug development for fibrodysplasia ossificans progressiva | Expert Opinion on Orphan Drugs | 2013 | 30 |
| 21 | Clinical features, genetics and potential therapeutic approaches for Birt–Hogg–Dubé syndrome | Expert Opinion on Orphan Drugs | 2015 | 30 |
| 22 | Translating HDAC inhibitors in Friedreich’s ataxia | Expert Opinion on Orphan Drugs | 2016 | 30 |
| 23 | Emerging and investigational therapies for neuroblastoma | Expert Opinion on Orphan Drugs | 2017 | 30 |
| 24 | Tissue chips to aid drug development and modeling for rare diseases | Expert Opinion on Orphan Drugs | 2016 | 29 |
| 25 | Pharmacological therapeutics targeting the secondary defects and downstream pathology of Duchenne muscular dystrophy | Expert Opinion on Orphan Drugs | 2016 | 29 |
| 26 | Epidemiology, pathogenesis and diagnosis of lymphangioleiomyomatosis | Expert Opinion on Orphan Drugs | 2016 | 29 |
| 27 | Obstacles and future of gene therapy for hemophilia | Expert Opinion on Orphan Drugs | 2015 | 28 |
| 28 | Advances in the treatment of neuronal ceroid lipofuscinosis | Expert Opinion on Orphan Drugs | 2019 | 28 |
| 29 | New therapeutic targets in rare genetic skeletal diseases | Expert Opinion on Orphan Drugs | 2015 | 27 |
| 30 | Pain in Ehlers-Danlos syndromes: manifestations, therapeutic strategies and future perspectives | Expert Opinion on Orphan Drugs | 2016 | 27 |
| 31 | Short bowel syndrome – characterisation of an orphan condition with many phenotypes | Expert Opinion on Orphan Drugs | 2013 | 26 |
| 32 | Genetics and prospective therapeutic targets for Sjögren-Larsson Syndrome | Expert Opinion on Orphan Drugs | 2016 | 26 |
| 33 | Therapies of mucopolysaccharidosis IVA (Morquio A syndrome) | Expert Opinion on Orphan Drugs | 2013 | 23 |
| 34 | Advances in understanding disease mechanisms and potential treatments for Crigler–Najjar syndrome | Expert Opinion on Orphan Drugs | 2018 | 23 |
| 35 | Emerging therapies and therapeutic concepts for lysosomal storage diseases | Expert Opinion on Orphan Drugs | 2013 | 22 |
| 36 | Management of acute intermittent porphyria | Expert Opinion on Orphan Drugs | 2014 | 22 |
| 37 | Treatment options for osteogenesis imperfecta | Expert Opinion on Orphan Drugs | 2015 | 20 |
| 38 | Improvement in vision: a new goal for treatment of hereditary retinal degenerations | Expert Opinion on Orphan Drugs | 2015 | 20 |
| 39 | Naegleria fowleri: diagnosis, treatment options and pathogenesis | Expert Opinion on Orphan Drugs | 2019 | 20 |
| 40 | Recombinant adeno-associated virus vectors in the treatment of rare diseases | Expert Opinion on Orphan Drugs | 2015 | 18 |
| 41 | Glycerol phenylbutyrate for the maintenance treatment of patients with deficiencies in enzymes of the urea cycle | Expert Opinion on Orphan Drugs | 2017 | 18 |
| 42 | Antisense oligonucleotide development for the treatment of muscular dystrophies | Expert Opinion on Orphan Drugs | 2016 | 17 |
| 43 | Diagnosis and genetics of Marfan syndrome | Expert Opinion on Orphan Drugs | 2014 | 16 |
| 44 | Development and validation of an MCDA framework for evaluation and decision-making of orphan drugs in Spain | Expert Opinion on Orphan Drugs | 2019 | 16 |
| 45 | Pathogenesis, clinical features and diagnosis of sarcoglycanopathies | Expert Opinion on Orphan Drugs | 2016 | 15 |
| 46 | Rare tumors in gynaecological cancers and the lack of therapeutic options and clinical trials | Expert Opinion on Orphan Drugs | 2017 | 15 |
| 47 | Druggable targets, clinical trial design and proposed pharmacological management in fibrodysplasia ossificans progressiva | Expert Opinion on Orphan Drugs | 2020 | 15 |
| 48 | Enzyme replacement therapy: lessons learned and emerging questions | Expert Opinion on Orphan Drugs | 2015 | 14 |
| 49 | New insights in primary ciliary dyskinesia | Expert Opinion on Orphan Drugs | 2017 | 14 |
| 50 | Clinical trial design for Friedreich ataxia - Where are we now and what do we need? | Expert Opinion on Orphan Drugs | 2018 | 14 |