7(top 2%)
Impact Factor
7.5(top 2%)
extended IF
122(top 3%)
H-Index
520
authors
1.3K
papers
65.7K
citations
5.1K
citing journals
31.4K
citing authors

Most Cited Articles of Drug Metabolism Reviews

TitleYearCitations
Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors1997969
Mechanistic studies of the Nrf2-Keap1 signaling pathway2006788
Summary of information on human CYP enzymes: human P450 metabolism data2002663
Quantification and significance of protein oxidation in biological samples2000595
Polymorphism of human cytochrome P450 enzymes and its clinical impact2009579
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity2012575
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies2007575
Pharmacokinetics and drug metabolism in the elderly2009483
Reactive oxygen-mediated protein oxidation in aging and disease1998454
The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds1990429
Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms2004426
Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins1994422
Structural and functional studies of UDP-glucuronosyltransferases1999417
Regulation of cytochromes P450 during inflammation and infection1997409
Inhibition of carcinogenesis by isothiocyanates2000370
Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?1992367
Inhibitors of Cytochrome P-450s and their mechanism of action1981362
Plasma and tissue protein binding of drugs in pharmacokinetics1976350
Reactive oxygen species in mitochondria-mediated cell death2007343
Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation1990337
Sex-related differences in drug metabolism1974336
The aldo-keto reductase superfamily and its role in drug metabolism and detoxification2008333
The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism2001327
Interactions of herbs with cytochrome P4502003320
Herbal modulation of P-glycoprotein2004316