| 1 | Multiple primary tumours: challenges and approaches, a review | ESMO Open | 2017 | 454 |
| 2 | NTRK gene fusions as novel targets of cancer therapy across multiple tumour types | ESMO Open | 2016 | 445 |
| 3 | Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended 4-year follow-up of the phase III CheckMate 214 trial | ESMO Open | 2020 | 405 |
| 4 | Mechanisms of resistance to EGFR-targeted drugs: lung cancer | ESMO Open | 2016 | 366 |
| 5 | Real-world application of tumor mutational burden-high (TMB-high) and microsatellite instability (MSI) confirms their utility as immunotherapy biomarkers | ESMO Open | 2022 | 261 |
| 6 | Implementing TMB measurement in clinical practice: considerations on assay requirements | ESMO Open | 2019 | 256 |
| 7 | Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer | ESMO Open | 2017 | 252 |
| 8 | Durvalumab, with or without tremelimumab, plus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer: 3-year overall survival update from CASPIAN | ESMO Open | 2022 | 237 |
| 9 | Cancer and liver cirrhosis: implications on prognosis and management | ESMO Open | 2016 | 215 |
| 10 | Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management | ESMO Open | 2018 | 209 |
| 11 | Global cancer control: responding to the growing burden, rising costs and inequalities in access | ESMO Open | 2018 | 202 |
| 12 | Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management | ESMO Open | 2019 | 191 |
| 13 | Descriptive statistical analysis of a real life cohort of 2419 patients with brain metastases of solid cancers | ESMO Open | 2016 | 187 |
| 14 | Cardiotoxicity of immune checkpoint inhibitors | ESMO Open | 2017 | 186 |
| 15 | Adolescents and young adults (AYA) with cancer: a position paper from the AYA Working Group of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE) | ESMO Open | 2021 | 181 |
| 16 | Pooled analysis of drug-related interstitial lung disease and/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies | ESMO Open | 2022 | 163 |
| 17 | Modulation of peripheral blood immune cells by early use of steroids and its association with clinical outcomes in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors | ESMO Open | 2019 | 162 |
| 18 | STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort | ESMO Open | 2020 | 162 |
| 19 | Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment | ESMO Open | 2022 | 161 |
| 20 | Biology of premature ageing in survivors of cancer | ESMO Open | 2017 | 147 |
| 21 | Pertuzumab and trastuzumab emtansine in patients with HER2-amplified metastatic colorectal cancer: the phase II HERACLES-B trial | ESMO Open | 2020 | 147 |
| 22 | Predictive role of microsatellite instability for PD-1 blockade in patients with advanced gastric cancer: a meta-analysis of randomized clinical trials | ESMO Open | 2021 | 136 |
| 23 | Targeting HER2 in non-small-cell lung cancer (NSCLC): a glimpse of hope? An updated review on therapeutic strategies in NSCLC harbouring HER2 alterations | ESMO Open | 2021 | 136 |
| 24 | Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort | ESMO Open | 2016 | 134 |
| 25 | The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy | ESMO Open | 2020 | 133 |
| 26 | Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts | ESMO Open | 2021 | 131 |
| 27 | Hallmarks of glioblastoma: a systematic review | ESMO Open | 2016 | 128 |
| 28 | Targeting immune checkpoints in breast cancer: an update of early results | ESMO Open | 2017 | 128 |
| 29 | First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update | ESMO Open | 2021 | 128 |
| 30 | Gender and outcomes in non-small cell lung cancer: an old prognostic variable comes back for targeted therapy and immunotherapy? | ESMO Open | 2018 | 127 |
| 31 | Tumour-infiltrating lymphocytes are correlated with higher expression levels of PD-1 and PD-L1 in early breast cancer | ESMO Open | 2017 | 122 |
| 32 | Challenge of cancer in the elderly | ESMO Open | 2016 | 120 |
| 33 | The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022 | ESMO Open | 2023 | 120 |
| 34 | Comprehensive clinical and molecular characterization of claudin 18.2 expression in advanced gastric or gastroesophageal junction cancer | ESMO Open | 2023 | 118 |
| 35 | Activating HER2 mutations as emerging targets in multiple solid cancers | ESMO Open | 2017 | 117 |
| 36 | Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls | ESMO Open | 2016 | 114 |
| 37 | The role of homologous recombination deficiency testing in ovarian cancer and its clinical implications: do we need it? | ESMO Open | 2021 | 108 |
| 38 | Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer | ESMO Open | 2022 | 104 |
| 39 | Anti-TIGIT therapies for solid tumors: a systematic review | ESMO Open | 2023 | 104 |
| 40 | Evolution of overall survival and receipt of new therapies by subtype among 20 446 metastatic breast cancer patients in the 2008-2017 ESME cohort | ESMO Open | 2021 | 102 |
| 41 | How I treat biliary tract cancer | ESMO Open | 2022 | 101 |
| 42 | Severe steroid-resistant anti-PD1 T-cell checkpoint inhibitor-induced hepatotoxicity driven by biliary injury | ESMO Open | 2017 | 99 |
| 43 | The prognostic impact of tumor mutational burden (TMB) in the first-line management of advanced non-oncogene addicted non-small-cell lung cancer (NSCLC): a systematic review and meta-analysis of randomized controlled trials | ESMO Open | 2021 | 96 |
| 44 | How we treat esophageal squamous cell carcinoma | ESMO Open | 2023 | 96 |
| 45 | Atezolizumab plus bevacizumab versus lenvatinib or sorafenib in non-viral unresectable hepatocellular carcinoma: an international propensity score matching analysis | ESMO Open | 2022 | 95 |
| 46 | Final results of the large-scale multinational trial PROFILE 1005: efficacy and safety of crizotinib in previously treated patients with advanced/metastatic ALK-positive non-small-cell lung cancer | ESMO Open | 2017 | 94 |
| 47 | Prospective experimental treatment of colorectal cancer patients based on organoid drug responses | ESMO Open | 2021 | 93 |
| 48 | Beyond epidermal growth factor receptor: MET amplification as a general resistance driver to targeted therapy in oncogene-driven non-small-cell lung cancer | ESMO Open | 2021 | 91 |
| 49 | Tobacco smoking and cessation and PD-L1 inhibitors in non-small cell lung cancer (NSCLC): a review of the literature | ESMO Open | 2018 | 90 |
| 50 | Impact of COVID-19 on anxiety levels among patients with cancer actively treated with systemic therapy | ESMO Open | 2020 | 90 |