| 1 | Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 1,272 |
| 2 | Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 728 |
| 3 | Caco-2 cell permeability assays to measure drug absorption | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 520 |
| 4 | The Simcyp®Population-based ADME Simulator | Expert Opinion on Drug Metabolism and Toxicology | 2009 | 484 |
| 5 | The Caco-2 cell monolayer: usefulness and limitations | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 446 |
| 6 | Zebrafish assays for drug toxicity screening | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 261 |
| 7 | Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 246 |
| 8 | Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 240 |
| 9 | The effect of chronic renal failure on drug metabolism and transport | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 220 |
| 10 | The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human | Expert Opinion on Drug Metabolism and Toxicology | 2012 | 216 |
| 11 | Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine | Expert Opinion on Drug Metabolism and Toxicology | 2018 | 216 |
| 12 | Minimising the potential for metabolic activation in drug discovery | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 214 |
| 13 | Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 208 |
| 14 | Pharmacokinetic properties and drug interactions of apigenin, a natural flavone | Expert Opinion on Drug Metabolism and Toxicology | 2017 | 207 |
| 15 | The rise of PAMPA | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 206 |
| 16 | In silicoADME-Tox modeling: progress and prospects | Expert Opinion on Drug Metabolism and Toxicology | 2017 | 205 |
| 17 | ABCG2: structure, function and role in drug response | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 193 |
| 18 | In vitromodels of the human epithelial airway barrier to study the toxic potential of particulate matter | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 188 |
| 19 | Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 186 |
| 20 | Intestinal efflux transporters and drug absorption | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 185 |
| 21 | Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 181 |
| 22 | Is curcumin bioavailability a problem in humans: lessons from clinical trials | Expert Opinion on Drug Metabolism and Toxicology | 2019 | 179 |
| 23 | The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders | Expert Opinion on Drug Metabolism and Toxicology | 2007 | 176 |
| 24 | Whole-body physiologically based pharmacokinetic models | Expert Opinion on Drug Metabolism and Toxicology | 2007 | 172 |
| 25 | Sex-specific differences in CYP450 isoforms in humans | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 170 |
| 26 | Ambroxol in the 21st century: pharmacological and clinical update | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 170 |
| 27 | Luminogenic cytochrome P450 assays | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 168 |
| 28 | The influence of circadian rhythms on the kinetics of drugs in humans | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 165 |
| 29 | Dexmedetomidine: sedation, analgesia and beyond | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 160 |
| 30 | Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies | Expert Opinion on Drug Metabolism and Toxicology | 2011 | 156 |
| 31 | Regulation of drug metabolism and disposition during inflammation and infection | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 155 |
| 32 | Drug-induced mitochondrial toxicity | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 155 |
| 33 | Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease | Expert Opinion on Drug Metabolism and Toxicology | 2016 | 152 |
| 34 | The road map to oral bioavailability: an industrial perspective | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 151 |
| 35 | Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions | Expert Opinion on Drug Metabolism and Toxicology | 2017 | 151 |
| 36 | Preclinical formulations for discovery and toxicology: physicochemical challenges | Expert Opinion on Drug Metabolism and Toxicology | 2006 | 146 |
| 37 | ABC transporters at the blood–brain barrier | Expert Opinion on Drug Metabolism and Toxicology | 2016 | 145 |
| 38 | Structure – ADME relationship: still a long way to go? | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 142 |
| 39 | Comparison of the pharmacokinetic and pharmacodynamic profiles of insulin degludec and insulin glargine | Expert Opinion on Drug Metabolism and Toxicology | 2015 | 139 |
| 40 | Metabolic activation of carboxylic acids | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 138 |
| 41 | Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 136 |
| 42 | Natural polyphenol disposition via coupled metabolic pathways | Expert Opinion on Drug Metabolism and Toxicology | 2007 | 136 |
| 43 | Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects | Expert Opinion on Drug Metabolism and Toxicology | 2020 | 134 |
| 44 | Mitochondrial toxicity assessment in industry – a decade of technology development and insight | Expert Opinion on Drug Metabolism and Toxicology | 2014 | 133 |
| 45 | Role of the aryl hydrocarbon receptor in drug metabolism | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 131 |
| 46 | Precision-cut tissue slices as a tool to predict metabolism of novel drugs | Expert Opinion on Drug Metabolism and Toxicology | 2007 | 130 |
| 47 | From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools | Expert Opinion on Drug Metabolism and Toxicology | 2005 | 129 |
| 48 | Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both? | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 129 |
| 49 | A review of valproate in psychiatric practice | Expert Opinion on Drug Metabolism and Toxicology | 2009 | 128 |
| 50 | The pregnane X receptor: from bench to bedside | Expert Opinion on Drug Metabolism and Toxicology | 2008 | 127 |