| 1 | Biofilm Formation Mechanisms and Targets for Developing Antibiofilm Agents | Future Medicinal Chemistry | 2015 | 651 |
| 2 | Cannabinoids as Novel Anti-Inflammatory Drugs | Future Medicinal Chemistry | 2009 | 472 |
| 3 | Macrocycles In New Drug Discovery | Future Medicinal Chemistry | 2012 | 443 |
| 4 | Marine Natural Products: A New Wave of Drugs? | Future Medicinal Chemistry | 2011 | 381 |
| 5 | Targeted Cancer Therapy: Giving Histone Deacetylase Inhibitors All They Need To Succeed | Future Medicinal Chemistry | 2012 | 369 |
| 6 | Inhibition of Ras for Cancer Treatment: The Search Continues | Future Medicinal Chemistry | 2011 | 361 |
| 7 | Strategies for Discovering and Derisking Covalent, Irreversible Enzyme Inhibitors | Future Medicinal Chemistry | 2010 | 349 |
| 8 | Atropisomerism in Medicinal Chemistry: Challenges and Opportunities | Future Medicinal Chemistry | 2018 | 335 |
| 9 | Therapeutic Potential of Boron-Containing Compounds | Future Medicinal Chemistry | 2009 | 334 |
| 10 | Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights | Future Medicinal Chemistry | 2009 | 324 |
| 11 | Photoaffinity Labeling in Target- and Binding-Site Identification | Future Medicinal Chemistry | 2015 | 315 |
| 12 | Structural Insights into G-Quadruplexes: Towards New Anticancer Drugs | Future Medicinal Chemistry | 2010 | 310 |
| 13 | Therapeutic Peptides | Future Medicinal Chemistry | 2012 | 300 |
| 14 | An Overview of Drug Discovery and Development | Future Medicinal Chemistry | 2020 | 297 |
| 15 | Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders | Future Medicinal Chemistry | 2010 | 293 |
| 16 | Iminosugars as Therapeutic Agents: Recent Advances and Promising Trends | Future Medicinal Chemistry | 2011 | 290 |
| 17 | Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor | Future Medicinal Chemistry | 2009 | 279 |
| 18 | Mirna-Based Therapies: Strategies and Delivery Platforms for Oligonucleotide and Non-Oligonucleotide Agents | Future Medicinal Chemistry | 2014 | 277 |
| 19 | Carbonic Anhydrase Inhibitors and Activators for Novel Therapeutic Applications | Future Medicinal Chemistry | 2011 | 275 |
| 20 | An Insight on Bacterial Cellular Targets of Photodynamic Inactivation | Future Medicinal Chemistry | 2014 | 267 |
| 21 | Agents that Inhibit Bacterial Biofilm Formation | Future Medicinal Chemistry | 2015 | 255 |
| 22 | Human copper transporters: mechanism, role in human diseases and therapeutic potential | Future Medicinal Chemistry | 2009 | 249 |
| 23 | Protein Tyrosine Phosphatases as Drug Targets: Strategies and Challenges of Inhibitor Development | Future Medicinal Chemistry | 2010 | 248 |
| 24 | Boron Chemicals in Diagnosis and Therapeutics | Future Medicinal Chemistry | 2013 | 248 |
| 25 | Fentanyl-Related Compounds and Derivatives: Current Status and Future Prospects for Pharmaceutical Applications | Future Medicinal Chemistry | 2014 | 247 |
| 26 | Targeting Protein–Protein Interactions for Therapeutic Intervention: A Challenge for the Future | Future Medicinal Chemistry | 2009 | 237 |
| 27 | Conformational Restriction: An Effective Tactic in ‘Follow-On’-Based Drug Discovery | Future Medicinal Chemistry | 2014 | 234 |
| 28 | Synthetic and natural iron chelators: therapeutic potential and clinical use | Future Medicinal Chemistry | 2009 | 221 |
| 29 | The Potentiality Of Vanadium In Medicinal Applications | Future Medicinal Chemistry | 2012 | 217 |
| 30 | Drug-Permeability and Transporter Assays in Caco-2 and Mdck Cell Lines | Future Medicinal Chemistry | 2011 | 216 |
| 31 | miRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart | Future Medicinal Chemistry | 2015 | 213 |
| 32 | Sulfonamides and Their Isosters As Carbonic Anhydrase Inhibitors | Future Medicinal Chemistry | 2014 | 203 |
| 33 | JNK Pathway Signaling: A Novel and Smarter Therapeutic Target for Various Biological Diseases | Future Medicinal Chemistry | 2015 | 191 |
| 34 | Conformational Adaptation in Drug–Target Interactions and Residence Time | Future Medicinal Chemistry | 2011 | 190 |
| 35 | Designing Photosensitizers for Photodynamic Therapy: Strategies, Challenges and Promising Developments | Future Medicinal Chemistry | 2009 | 186 |
| 36 | Targeting Cancer Cell Mitochondria as a Therapeutic Approach | Future Medicinal Chemistry | 2013 | 182 |
| 37 | Magnetic Iron Oxide Nanoparticles for Biomedical Applications | Future Medicinal Chemistry | 2010 | 180 |
| 38 | Reactive Oxygen Species-Inducing Antifungal Agents and Their Activity Against Fungal Biofilms | Future Medicinal Chemistry | 2014 | 176 |
| 39 | The PI3K/Akt/PTEN/mTOR Pathway: A Fruitful Target for Inducing Cell Death in Rheumatoid Arthritis? | Future Medicinal Chemistry | 2015 | 176 |
| 40 | Progress in the Medicinal Chemistry of Silicon: C/Si Exchange and Beyond | Future Medicinal Chemistry | 2017 | 176 |
| 41 | Quercetin and Derivatives: Useful Tools in Inflammation and Pain Management | Future Medicinal Chemistry | 2017 | 176 |
| 42 | Thiosemicarbazones: the new wave in cancer treatment | Future Medicinal Chemistry | 2009 | 174 |
| 43 | Observations on Screening-Based Research and Some Concerning Trends in the Literature | Future Medicinal Chemistry | 2010 | 174 |
| 44 | Gallium-Containing Anticancer Compounds | Future Medicinal Chemistry | 2012 | 173 |
| 45 | Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products | Future Medicinal Chemistry | 2015 | 172 |
| 46 | Manufacturing Peptides as Active Pharmaceutical Ingredients | Future Medicinal Chemistry | 2009 | 167 |
| 47 | Sirtuin Inhibitors as Anticancer Agents | Future Medicinal Chemistry | 2014 | 167 |
| 48 | Heparanase: A Rainbow Pharmacological Target Associated to Multiple Pathologies Including Rare Diseases | Future Medicinal Chemistry | 2016 | 167 |
| 49 | Histone Deacetylase Inhibitors In The Treatment Of Cancer: Overview And Perspectives | Future Medicinal Chemistry | 2012 | 164 |
| 50 | Chromenes: Potential New Chemotherapeutic Agents for Cancer | Future Medicinal Chemistry | 2013 | 162 |