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Top Articles

1Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1Cancer Cell20106,138
2Accessories to the Crime: Functions of Cells Recruited to the Tumor MicroenvironmentCancer Cell20123,578
3Tensional homeostasis and the malignant phenotypeCancer Cell20053,397
4Immune Checkpoint Blockade: A Common Denominator Approach to Cancer TherapyCancer Cell20153,266
5Integrative Genomic Profiling of Human Prostate CancerCancer Cell20103,151
6Unique microRNA molecular profiles in lung cancer diagnosis and prognosisCancer Cell20062,870
7A collection of breast cancer cell lines for the study of functionally distinct cancer subtypesCancer Cell20062,729
8Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisCancer Cell20062,706
9Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosisCancer Cell20052,695
10Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not AnticipateCancer Cell20122,617
11Defining the Role of mTOR in CancerCancer Cell20072,610
12Long Noncoding RNAs in Cancer PathwaysCancer Cell20162,584
13Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TANCancer Cell20092,522
14Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent DioxygenasesCancer Cell20112,340
15Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic DifferentiationCancer Cell20102,328
16A multigenic program mediating breast cancer metastasis to boneCancer Cell20032,325
17Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant MetastasisCancer Cell20092,168
18Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseCancer Cell20032,150
19Gene expression correlates of clinical prostate cancer behaviorCancer Cell20022,144
20Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceCancer Cell20052,137
21Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of GliomaCancer Cell20102,078
22Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell linesCancer Cell20062,056
23A Perivascular Niche for Brain Tumor Stem CellsCancer Cell20071,994
24Tumor Cell Metabolism: Cancer's Achilles' HeelCancer Cell20081,926
25Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced SurvivalCancer Cell20141,892
26IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated CancerCancer Cell20091,851
27Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisCancer Cell20061,779
28Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylaseCancer Cell20051,764
29Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profilingCancer Cell20021,756
30The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-HydroxyglutarateCancer Cell20101,754
31PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patientsCancer Cell20041,693
32AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma PatientsCancer Cell20071,675
33Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal AdenocarcinomaCancer Cell20121,664
34Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor AngiogenesisCancer Cell20091,624
35Smoldering and polarized inflammation in the initiation and promotion of malignant diseaseCancer Cell20051,622
36Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal AdenocarcinomaCancer Cell20141,616
37Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of GlioblastomaCancer Cell20121,551
38Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemiaCancer Cell20021,548
39Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsCancer Cell20051,478
40Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes MetastasisCancer Cell20111,476
41The RB and p53 pathways in cancerCancer Cell20021,473
42A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast CancerCancer Cell20071,471
43Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsCancer Cell20021,467
44Nuclear factor-κBCancer Cell20041,428
45Integrated Genomic Characterization of Pancreatic Ductal AdenocarcinomaCancer Cell20171,428
46YAP/TAZ at the Roots of CancerCancer Cell20161,409
47Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of MetastasisCancer Cell20161,401
48A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular CarcinomaCancer Cell20141,392
49Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenanceCancer Cell20061,390
50Characterization of AMN107, a selective inhibitor of native and mutant Bcr-AblCancer Cell20051,387