(top 60%)
Impact Factor
(top 60%)
extended IF
194(top 1%)
H-Index
2.6K
authors
3.3K
papers
217.3K
citations
6.1K
citing journals
109.4K
citing authors

Most Cited Articles of Chemistry and Biology

TitleYearCitations
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs20101.2K
Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products19981.2K
A DNA enzyme that cleaves RNA19941K
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases1999937
Proteasome inhibitors: from research tools to drug candidates2001916
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol2007835
Vitamin D metabolism, mechanism of action, and clinical applications2014793
DNA-enhanced peroxidase activity of a DNA-aptamer-hemin complex1998793
An engineered protein tag for multiprotein labeling in living cells2008750
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription2000750
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization2006745
Small-molecule inhibitors of protein-protein interactions: progressing toward the reality2014699
RNA-based therapeutics: current progress and future prospects2012693
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system2000671
A new enzyme superfamily - the phosphopantetheinyl transferases1996664
Profiling enzyme activities in vivo using click chemistry methods2004654
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains2000639
GSK-3-selective inhibitors derived from Tyrian purple indirubins2003632
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells2008630
Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death2005595
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD42015591
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy1997585
Catalytic promiscuity and the evolution of new enzymatic activities1999582
Genetic control by a metabolite binding mRNA2002578
Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming1995564