1.9(top 9%)
Impact Factor
2(top 9%)
extended IF
133(top 2%)
H-Index
1.7K
authors
3.4K
papers
134.5K
citations
4.4K
citing journals
59.6K
citing authors

Most Cited Articles of Protein Engineering, Design and Selection

TitleYearCitations
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites19974.5K
LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions19953.8K
The alpha/beta hydrolase fold19921.7K
Protein structure alignment by incremental combinatorial extension (CE) of the optimal path19981.5K
Crystal structure of human serum albumin at 2.5 A resolution19991.3K
Twilight zone of protein sequence alignments19991.1K
ALSCRIPT: a tool to format multiple sequence alignments19931K
A new method for predicting binding affinity in computer-aided drug design1994950
Quantitative analysis of protein far UV circular dichroism spectra by neural networks1992909
Feature-based prediction of non-classical and leaderless protein secretion2004873
Evaluation of secondary structure of proteins from UV circular dichroism spectra using an unsupervised learning neural network1993855
Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method1997831
Single-stranded DNA 'blue' T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering1986718
Conformational change of proteins arising from normal mode calculations2001716
Factors enhancing protein thermostability2000663
Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence1990656
Analysis and prediction of leucine-rich nuclear export signals2004613
Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency2001611
Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering1990581
A synthetic IgG-binding domain based on staphylococcal protein A1987577
An attempt to unify the structure of polymerases1990517
'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization1996468
Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 21988467
Machine learning approaches for the prediction of signal peptides and other protein sorting signals1999461
Folding funnels and binding mechanisms1999451