| 1 | Epigenetic reprogramming in mouse primordial germ cells | Mechanisms of Development | 2002 | 1,122 |
| 2 | Reiterative signaling and patterning during mammalian tooth morphogenesis | Mechanisms of Development | 2000 | 1,004 |
| 3 | Stages of normal development in the medaka Oryzias latipes | Mechanisms of Development | 2004 | 906 |
| 4 | Nuclear localization of β-catenin by interaction with transcription factor LEF-1 | Mechanisms of Development | 1996 | 832 |
| 5 | Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro | Mechanisms of Development | 1996 | 750 |
| 6 | The molecular basis of lung morphogenesis | Mechanisms of Development | 2000 | 697 |
| 7 | Five years on the wings of fork head | Mechanisms of Development | 1996 | 639 |
| 8 | Gal4 in the Drosophila female germline | Mechanisms of Development | 1998 | 634 |
| 9 | The role of hepatocytes and oval cells in liver regeneration and repopulation | Mechanisms of Development | 2003 | 614 |
| 10 | Signalling networks regulating dental development | Mechanisms of Development | 1997 | 582 |
| 11 | Mouse gastrulation: the formation of a mammalian body plan | Mechanisms of Development | 1997 | 571 |
| 12 | The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo | Mechanisms of Development | 1993 | 555 |
| 13 | The LIM domain: regulation by association | Mechanisms of Development | 2000 | 527 |
| 14 | Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development | Mechanisms of Development | 2003 | 524 |
| 15 | Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages | Mechanisms of Development | 1999 | 521 |
| 16 | Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development | Mechanisms of Development | 2000 | 517 |
| 17 | I-SceI meganuclease mediates highly efficient transgenesis in fish | Mechanisms of Development | 2002 | 513 |
| 18 | β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos | Mechanisms of Development | 1996 | 509 |
| 19 | Does adult fracture repair recapitulate embryonic skeletal formation? | Mechanisms of Development | 1999 | 504 |
| 20 | Intestinal growth and differentiation in zebrafish | Mechanisms of Development | 2005 | 502 |
| 21 | Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development | Mechanisms of Development | 1997 | 496 |
| 22 | Role of endothelial cells in early pancreas and liver development | Mechanisms of Development | 2003 | 493 |
| 23 | Generating green fluorescent mice by germline transmission of green fluorescent ES cells | Mechanisms of Development | 1998 | 466 |
| 24 | Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain | Mechanisms of Development | 2002 | 465 |
| 25 | Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation | Mechanisms of Development | 1998 | 464 |
| 26 | Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos | Mechanisms of Development | 2008 | 464 |
| 27 | Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis | Mechanisms of Development | 2001 | 463 |
| 28 | Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types | Mechanisms of Development | 1993 | 460 |
| 29 | Left–right asymmetry in embryonic development: a comprehensive review | Mechanisms of Development | 2005 | 452 |
| 30 | Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula | Mechanisms of Development | 1997 | 448 |
| 31 | Regulation of chondrocyte differentiation by Cbfa1 | Mechanisms of Development | 1999 | 436 |
| 32 | Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development | Mechanisms of Development | 1995 | 418 |
| 33 | Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 | Mechanisms of Development | 2002 | 411 |
| 34 | Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4 | Mechanisms of Development | 2000 | 401 |
| 35 | Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels | Mechanisms of Development | 2001 | 396 |
| 36 | Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system | Mechanisms of Development | 1993 | 394 |
| 37 | Use of the Gal4-UAS technique for targeted gene expression in the zebrafish | Mechanisms of Development | 1999 | 392 |
| 38 | The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system | Mechanisms of Development | 1990 | 369 |
| 39 | Prox 1, a prospero-related homeobox gene expressed during mouse development | Mechanisms of Development | 1993 | 367 |
| 40 | The enamel knot as a signaling center in the developing mouse tooth | Mechanisms of Development | 1996 | 366 |
| 41 | Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development | Mechanisms of Development | 1995 | 365 |
| 42 | Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3 | Mechanisms of Development | 2000 | 364 |
| 43 | Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation | Mechanisms of Development | 2001 | 363 |
| 44 | Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase | Mechanisms of Development | 2007 | 358 |
| 45 | Cell lineage in mammalian craniofacial mesenchyme | Mechanisms of Development | 2008 | 354 |
| 46 | HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels | Mechanisms of Development | 1997 | 353 |
| 47 | Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas | Mechanisms of Development | 2009 | 351 |
| 48 | The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4 | Mechanisms of Development | 1997 | 349 |
| 49 | Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair | Mechanisms of Development | 1998 | 342 |
| 50 | Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons | Mechanisms of Development | 1995 | 337 |