| 1 | Fluorine in Medicinal Chemistry | ChemBioChem | 2004 | 1,355 |
| 2 | The Unique Role of Fluorine in the Design of Active Ingredients for Modern Crop Protection | ChemBioChem | 2004 | 1,176 |
| 3 | Big Effects from Small Changes: Possible Ways to Explore Nature's Chemical Diversity | ChemBioChem | 2002 | 965 |
| 4 | Hydrogenases: Hydrogen-Activating Enzymes | ChemBioChem | 2002 | 726 |
| 5 | Design of Gold Nanoparticle‐Based Colorimetric Biosensing Assays | ChemBioChem | 2008 | 683 |
| 6 | Giant Vesicles: Preparations and Applications | ChemBioChem | 2010 | 621 |
| 7 | Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV | ChemBioChem | 2020 | 584 |
| 8 | Coiled Coil Domains: Stability, Specificity, and Biological Implications | ChemBioChem | 2004 | 576 |
| 9 | Extracellular Synthesis of Gold Nanoparticles by the Fungus Fusarium oxysporum | ChemBioChem | 2002 | 546 |
| 10 | Structure and Function of Mammalian DNA Methyltransferases | ChemBioChem | 2011 | 542 |
| 11 | Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases | ChemBioChem | 2002 | 511 |
| 12 | Close-Range Electrostatic Interactions in Proteins | ChemBioChem | 2002 | 446 |
| 13 | Chemical Biology of the Sugar Code | ChemBioChem | 2004 | 440 |
| 14 | Drug Design Strategies for Targeting G-Protein-Coupled Receptors | ChemBioChem | 2002 | 439 |
| 15 | The Polar Hydrophobicity of Fluorinated Compounds | ChemBioChem | 2004 | 413 |
| 16 | NMR Spectroscopy of RNA | ChemBioChem | 2003 | 397 |
| 17 | Organic Fluorine: Odd Man Out | ChemBioChem | 2004 | 385 |
| 18 | The Outstanding Biological Stability ofβ- andγ-Peptides toward Proteolytic Enzymes: An In Vitro Investigation with Fifteen Peptidases | ChemBioChem | 2001 | 379 |
| 19 | Ways of Assembling Complex Natural Products on Modular Nonribosomal Peptide Synthetases A list of abbreviations can be found at the end of the text. | ChemBioChem | 2002 | 375 |
| 20 | The α-to-β Conformational Transition of Alzheimer's Aβ-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of β Conformation Seeding | ChemBioChem | 2006 | 369 |
| 21 | Molecular Assembly of an Aptamer–Drug Conjugate for Targeted Drug Delivery to Tumor Cells | ChemBioChem | 2009 | 348 |
| 22 | S‐Adenosyl‐Methionine‐Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications | ChemBioChem | 2012 | 338 |
| 23 | Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action | ChemBioChem | 2007 | 329 |
| 24 | Addressing the Numbers Problem in Directed Evolution | ChemBioChem | 2008 | 328 |
| 25 | Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases | ChemBioChem | 2003 | 319 |
| 26 | Wall Teichoic Acid Function, Biosynthesis, and Inhibition | ChemBioChem | 2010 | 315 |
| 27 | Chemical Protein Modification through Cysteine | ChemBioChem | 2016 | 313 |
| 28 | Backbone and Side-Chain13C and15N Signal Assignments of the α-Spectrin SH3 Domain by Magic Angle Spinning Solid-State NMR at 17.6 Tesla | ChemBioChem | 2001 | 296 |
| 29 | Targeting Mitochondria with Organelle‐Specific Compounds: Strategies and Applications | ChemBioChem | 2009 | 290 |
| 30 | Surface Coating with Cyclic RGD Peptides Stimulates Osteoblast Adhesion and Proliferation as well as Bone Formation | ChemBioChem | 2000 | 278 |
| 31 | Gene Expression within Cell-Sized Lipid Vesicles | ChemBioChem | 2003 | 278 |
| 32 | NMR Spectroscopy of Paramagnetic Metalloproteins | ChemBioChem | 2005 | 271 |
| 33 | A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases | ChemBioChem | 2005 | 269 |
| 34 | Real-Time Polymerase Chain Reaction | ChemBioChem | 2003 | 265 |
| 35 | Strategies for the Discovery of New Natural Products by Genome Mining | ChemBioChem | 2009 | 265 |
| 36 | Quorum Sensing and Quorum Quenching: The Yin and Yang of Bacterial Communication | ChemBioChem | 2009 | 263 |
| 37 | 1,2,3-Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV-1 Protease Inhibitors | ChemBioChem | 2005 | 253 |
| 38 | Extracellular Synthesis of Crystalline Silver Nanoparticles and Molecular Evidence of Silver Resistance from Morganella sp.: Towards Understanding Biochemical Synthesis Mechanism | ChemBioChem | 2008 | 253 |
| 39 | Copper and Zinc Binding to Amyloid‐β: Coordination, Dynamics, Aggregation, Reactivity and Metal‐Ion Transfer | ChemBioChem | 2009 | 246 |
| 40 | Natural Products from Marine Organisms and Their Associated Microbes | ChemBioChem | 2006 | 245 |
| 41 | Redox Chemistry of Copper–Amyloid-β: The Generation of Hydroxyl Radical in the Presence of Ascorbate is Linked to Redox-Potentials and Aggregation State | ChemBioChem | 2007 | 244 |
| 42 | Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces | ChemBioChem | 2005 | 242 |
| 43 | Development of a Lectin Microarray for the Rapid Analysis of Protein Glycopatterns | ChemBioChem | 2005 | 241 |
| 44 | RNA Interference and Small Interfering RNAs | ChemBioChem | 2001 | 239 |
| 45 | Azobenzene as Conformational Switch in Model Peptides | ChemBioChem | 2006 | 238 |
| 46 | Use of Magnetic Nanoparticles as Nanosensors to Probe for Molecular Interactions | ChemBioChem | 2004 | 236 |
| 47 | Quantum-Dot Aptamer Beacons for the Detection of Proteins | ChemBioChem | 2005 | 236 |
| 48 | Genetic Control by Metabolite-Binding Riboswitches | ChemBioChem | 2003 | 235 |
| 49 | Halogenation of Drugs Enhances Membrane Binding and Permeation | ChemBioChem | 2004 | 222 |
| 50 | Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines | ChemBioChem | 2007 | 219 |
