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Top Articles

#TitleJournalYearCitations
1Multiple sequence alignment with Clustal XTrends in Biochemical Sciences19982,176
2Mechanism and Regulation of NLRP3 Inflammasome ActivationTrends in Biochemical Sciences20162,171
3Structure, mechanism and regulation of peroxiredoxinsTrends in Biochemical Sciences20032,098
4RASMOL: biomolecular graphics for allTrends in Biochemical Sciences19951,977
5Caspases: killer proteasesTrends in Biochemical Sciences19971,851
6Macromolecular crowding: obvious but underappreciatedTrends in Biochemical Sciences20011,745
7PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localizationTrends in Biochemical Sciences19991,741
8The P-loop — a common motif in ATP- and GTP-binding proteinsTrends in Biochemical Sciences19901,697
9The Nrf2 regulatory network provides an interface between redox and intermediary metabolismTrends in Biochemical Sciences20141,665
10Genomic DNA methylation: the mark and its mediatorsTrends in Biochemical Sciences20061,628
11Nuclear targeting sequences — a consensus?Trends in Biochemical Sciences19911,599
12Intrinsically unstructured proteinsTrends in Biochemical Sciences20021,573
13AU-rich elements: characterization and importance in mRNA degradationTrends in Biochemical Sciences19951,529
14Protein misfolding, evolution and diseaseTrends in Biochemical Sciences19991,513
15The economics of ribosome biosynthesis in yeastTrends in Biochemical Sciences19991,439
16NPS@: Network Protein Sequence AnalysisTrends in Biochemical Sciences20001,409
17PEST sequences and regulation by proteolysisTrends in Biochemical Sciences19961,312
18Glutamine addiction: a new therapeutic target in cancerTrends in Biochemical Sciences20101,297
19The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationTrends in Biochemical Sciences20111,297
20Dali: a network tool for protein structure comparisonTrends in Biochemical Sciences19951,269
21The glamour and gloom of glycogen synthase kinase-3Trends in Biochemical Sciences20041,207
22Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammationTrends in Biochemical Sciences20051,179
23Okadaic acid: a new probe for the study of cellular regulationTrends in Biochemical Sciences19901,161
24The pentose phosphate pathway and cancerTrends in Biochemical Sciences20141,069
25Promoter-specific activation of RNA polymerase II transcription by Sp1Trends in Biochemical Sciences19861,013
26Regulation of autophagy by ROS: physiology and pathologyTrends in Biochemical Sciences2011990
27Understanding, improving and using green fluorescent proteinsTrends in Biochemical Sciences1995989
28The WD repeat: a common architecture for diverse functionsTrends in Biochemical Sciences1999981
29Coiled coils: new structures and new functionsTrends in Biochemical Sciences1996971
30The leucine-rich repeat: a versatile binding motifTrends in Biochemical Sciences1994952
31The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signalingTrends in Biochemical Sciences2003940
32New insights into TGF-β–Smad signallingTrends in Biochemical Sciences2004913
33The regulation of protein function by multisite phosphorylation – a 25 year updateTrends in Biochemical Sciences2000909
34Ten years of protein kinase B signalling: a hard Akt to followTrends in Biochemical Sciences2001897
35The measurement and mechanism of lipid peroxidation in biological systemsTrends in Biochemical Sciences1990892
36TPR proteins: the versatile helixTrends in Biochemical Sciences2003883
37A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundanceTrends in Biochemical Sciences1998876
38UPR, autophagy, and mitochondria crosstalk underlies the ER stress responseTrends in Biochemical Sciences2015870
39The MAP kinase cascade is essential for diverse signal transduction pathwaysTrends in Biochemical Sciences1993860
40Mammalian cyclin-dependent kinasesTrends in Biochemical Sciences2005857
41Stress granules: the Tao of RNA triageTrends in Biochemical Sciences2008857
42The S100 family of EF-hand calcium-binding proteins: functions and pathologyTrends in Biochemical Sciences1996852
43The AMP-activated protein kinase cascade – a unifying system for energy controlTrends in Biochemical Sciences2004839
44Protein kinase recognition sequence motifsTrends in Biochemical Sciences1990837
45Functional amyloid – from bacteria to humansTrends in Biochemical Sciences2007814
46Parallel signal processing among mammalian MAPKsTrends in Biochemical Sciences1995802
47Ion motive ATPases. I. Ubiquity, properties, and significance to cell functionTrends in Biochemical Sciences1987792
48Too much of a good thing: light can be bad for photosynthesisTrends in Biochemical Sciences1992786
49Serine and glycine metabolism in cancerTrends in Biochemical Sciences2014786
50The glucose-regulated proteins: stress induction and clinical applicationsTrends in Biochemical Sciences2001783