4.7(top 3%)
Impact Factor
5(top 3%)
extended IF
252(top 1%)
H-Index
4.6K
authors
28.4K
papers
1M
citations
8K
citing journals
134.1K
citing authors

Most Cited Articles of Journal of Pharmacology and Experimental Therapeutics

TitleYearCitations
A simplified method of evaluating dose-effect experiments19493.7K
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog19762K
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians19941.7K
A method for the fluorometric assay of histamine in tissues19591.5K
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines19621.3K
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates19811.2K
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione19731.1K
Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines19531K
p-Chlorophenylalanine: a specific depletor of brain serotonin1966998
Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention2003916
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta1985913
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism1973880
Functional selectivity and classical concepts of quantitative pharmacology2007870
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity1973824
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors2000816
Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values1989801
The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development2003792
Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors2002768
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo1973722
Role of tyrosine kinase inhibitors in cancer therapy2005713
Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys2009709
Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic1992688
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats1988682
SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems1983657
Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy2003655