| 1 | Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria | Annals of Neurology | 2011 | 7,043 |
| 2 | Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria” | Annals of Neurology | 2005 | 3,799 |
| 3 | Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment | Annals of Neurology | 1991 | 3,141 |
| 4 | Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B | Annals of Neurology | 2004 | 3,074 |
| 5 | Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging | Annals of Neurology | 1999 | 2,497 |
| 6 | Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination | Annals of Neurology | 2000 | 2,340 |
| 7 | Temporal profile of neuronal damage in a model of transient forebrain ischemia | Annals of Neurology | 1982 | 2,111 |
| 8 | The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia | Annals of Neurology | 2004 | 2,035 |
| 9 | Glutamate and the pathophysiology of hypoxic–ischemic brain damage | Annals of Neurology | 1986 | 1,854 |
| 10 | Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma | Annals of Neurology | 2007 | 1,818 |
| 11 | Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis | Annals of Neurology | 1996 | 1,817 |
| 12 | Large‐scale neurocognitive networks and distributed processing for attention, language, and memory | Annals of Neurology | 1990 | 1,797 |
| 13 | A cortical network for directed attention and unilateral neglect | Annals of Neurology | 1981 | 1,792 |
| 14 | Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method | Annals of Neurology | 1979 | 1,704 |
| 15 | The influence of immaturity on hypoxic‐ischemic brain damage in the rat | Annals of Neurology | 1981 | 1,685 |
| 16 | Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity | Annals of Neurology | 1990 | 1,653 |
| 17 | Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects | Annals of Neurology | 2009 | 1,527 |
| 18 | Oxidative stress in Parkinson's disease | Annals of Neurology | 2003 | 1,486 |
| 19 | Neuroglial activation and neuroinflammation in the brain of patients with autism | Annals of Neurology | 2005 | 1,474 |
| 20 | Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease | Annals of Neurology | 1999 | 1,444 |
| 21 | Assessment of current diagnostic criteria for Guillain-Barr� syndrome | Annals of Neurology | 1990 | 1,372 |
| 22 | Perisylvian language networks of the human brain | Annals of Neurology | 2005 | 1,287 |
| 23 | Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis | Annals of Neurology | 1981 | 1,267 |
| 24 | Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease | Annals of Neurology | 1997 | 1,238 |
| 25 | Vasoactive peptide release in the extracerebral circulation of humans during migraine headache | Annals of Neurology | 1990 | 1,220 |
| 26 | The AIDS dementia complex: I. Clinical features | Annals of Neurology | 1986 | 1,216 |
| 27 | Tangles and plaques in nondemented aging and ?preclinical? Alzheimer's disease | Annals of Neurology | 1999 | 1,180 |
| 28 | Cognition and anatomy in three variants of primary progressive aphasia | Annals of Neurology | 2004 | 1,086 |
| 29 | Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro | Annals of Neurology | 1988 | 1,079 |
| 30 | Impairment of paravascular clearance pathways in the aging brain | Annals of Neurology | 2014 | 1,075 |
| 31 | Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis | Annals of Neurology | 1995 | 1,074 |
| 32 | Influence of interhemispheric interactions on motor function in chronic stroke | Annals of Neurology | 2004 | 1,067 |
| 33 | Aging, energy, and oxidative stress in neurodegenerative diseases | Annals of Neurology | 1995 | 1,062 |
| 34 | Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease | Annals of Neurology | 1997 | 1,055 |
| 35 | A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: Report of 35 cases | Annals of Neurology | 1983 | 1,048 |
| 36 | Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions | Annals of Neurology | 2001 | 1,023 |
| 37 | Positron emission tomography study of human brain functional development | Annals of Neurology | 1987 | 1,020 |
| 38 | Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients | Annals of Neurology | 1983 | 1,017 |
| 39 | Pathological verification of ischemic score in differentiation of dementias | Annals of Neurology | 1980 | 1,014 |
| 40 | Tau is a candidate gene for chromosome 17 frontotemporal dementia | Annals of Neurology | 1998 | 1,003 |
| 41 | Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects | Annals of Neurology | 1999 | 1,000 |
| 42 | 1,026 Experimental treatments in acute stroke | Annals of Neurology | 2006 | 983 |
| 43 | Rett syndrome: Revised diagnostic criteria and nomenclature | Annals of Neurology | 2010 | 966 |
| 44 | A double‐blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease | Annals of Neurology | 2003 | 952 |
| 45 | Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans | Annals of Neurology | 2006 | 922 |
| 46 | Viability thresholds and the penumbra of focal ischemia | Annals of Neurology | 1994 | 905 |
| 47 | The AIDS dementia complex: II. Neuropathology | Annals of Neurology | 1986 | 902 |
| 48 | Diffuse axonal injury and traumatic coma in the primate | Annals of Neurology | 1982 | 901 |
| 49 | Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndrome | Annals of Neurology | 1984 | 898 |
| 50 | The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats | Annals of Neurology | 1993 | 898 |