| 1 | Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification | Journal of Clinical Oncology | 2014 | 4,020 |
| 2 | One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States | Journal of Clinical Oncology | 2008 | 3,257 |
| 3 | Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update | Journal of Clinical Oncology | 2013 | 3,140 |
| 4 | Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer | Journal of Clinical Oncology | 2000 | 2,808 |
| 5 | Report of an International Workshop to Standardize Response Criteria for Non-Hodgkin's Lymphomas | Journal of Clinical Oncology | 1999 | 2,783 |
| 6 | Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients | Journal of Clinical Oncology | 2001 | 2,758 |
| 7 | Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group | Journal of Clinical Oncology | 2007 | 2,744 |
| 8 | Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline | Journal of Clinical Oncology | 2018 | 2,740 |
| 9 | Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World | Journal of Clinical Oncology | 2006 | 2,703 |
| 10 | How To Build and Interpret a Nomogram for Cancer Prognosis | Journal of Clinical Oncology | 2008 | 2,488 |
| 11 | Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2008 | 2,462 |
| 12 | American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer | Journal of Clinical Oncology | 2010 | 2,443 |
| 13 | Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer | Journal of Clinical Oncology | 2008 | 2,363 |
| 14 | Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma | Journal of Clinical Oncology | 2003 | 2,338 |
| 15 | Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study | Journal of Clinical Oncology | 2008 | 2,285 |
| 16 | Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis | Journal of Clinical Oncology | 2005 | 2,250 |
| 17 | Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study | Journal of Clinical Oncology | 2020 | 2,197 |
| 18 | Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer | Journal of Clinical Oncology | 2008 | 2,192 |
| 19 | International Staging System for Multiple Myeloma | Journal of Clinical Oncology | 2005 | 2,184 |
| 20 | Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2003 | 2,157 |
| 21 | FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study | Journal of Clinical Oncology | 2004 | 2,153 |
| 22 | Immune Checkpoint Blockade in Cancer Therapy | Journal of Clinical Oncology | 2015 | 2,128 |
| 23 | Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease | Journal of Clinical Oncology | 1999 | 1,962 |
| 24 | Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group | Journal of Clinical Oncology | 2008 | 1,954 |
| 25 | Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma | Journal of Clinical Oncology | 2015 | 1,949 |
| 26 | Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma | Journal of Clinical Oncology | 2001 | 1,884 |
| 27 | Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy | Journal of Clinical Oncology | 2004 | 1,841 |
| 28 | Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer | Journal of Clinical Oncology | 2006 | 1,798 |
| 29 | Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update | Journal of Clinical Oncology | 2018 | 1,750 |
| 30 | Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix | Journal of Clinical Oncology | 2000 | 1,712 |
| 31 | Bevacizumab in Combination With Oxaliplatin, Fluorouracil, and Leucovorin (FOLFOX4) for Previously Treated Metastatic Colorectal Cancer: Results From the Eastern Cooperative Oncology Group Study E3200 | Journal of Clinical Oncology | 2007 | 1,707 |
| 32 | Gemcitabine and Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Advanced or Metastatic Bladder Cancer: Results of a Large, Randomized, Multinational, Multicenter, Phase III Study | Journal of Clinical Oncology | 2000 | 1,681 |
| 33 | Liquid Biopsies: Genotyping Circulating Tumor DNA | Journal of Clinical Oncology | 2014 | 1,678 |
| 34 | Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor | Journal of Clinical Oncology | 2003 | 1,665 |
| 35 | A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer | Journal of Clinical Oncology | 2004 | 1,663 |
| 36 | International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical Outcomes | Journal of Clinical Oncology | 2008 | 1,560 |
| 37 | Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study | Journal of Clinical Oncology | 2003 | 1,556 |
| 38 | Randomized Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy and Palliative Surgery in Patients With Peritoneal Carcinomatosis of Colorectal Cancer | Journal of Clinical Oncology | 2003 | 1,555 |
| 39 | Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer | Journal of Clinical Oncology | 1999 | 1,526 |
| 40 | Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer | Journal of Clinical Oncology | 2005 | 1,517 |
| 41 | Phase III Study of Docetaxel and Cisplatin Plus Fluorouracil Compared With Cisplatin and Fluorouracil As First-Line Therapy for Advanced Gastric Cancer: A Report of the V325 Study Group | Journal of Clinical Oncology | 2006 | 1,471 |
| 42 | Long-Term Survival Results of a Randomized Trial Comparing Gemcitabine Plus Cisplatin, With Methotrexate, Vinblastine, Doxorubicin, Plus Cisplatin in Patients With Bladder Cancer | Journal of Clinical Oncology | 2005 | 1,468 |
| 43 | Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results Database | Journal of Clinical Oncology | 2006 | 1,442 |
| 44 | Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer | Journal of Clinical Oncology | 2004 | 1,435 |
| 45 | High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993 | Journal of Clinical Oncology | 1999 | 1,434 |
| 46 | Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer | Journal of Clinical Oncology | 2007 | 1,430 |
| 47 | Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update | Journal of Clinical Oncology | 2017 | 1,422 |
| 48 | Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update | Journal of Clinical Oncology | 2021 | 1,410 |
| 49 | Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer | Journal of Clinical Oncology | 2008 | 1,388 |
| 50 | Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial | Journal of Clinical Oncology | 2020 | 1,387 |