8.3(top 1%)
Impact Factor
8.7(top 1%)
extended IF
305(top 1%)
H-Index
15.5K
authors
31.3K
papers
1.4M
citations
9.7K
citing journals
215.3K
citing authors

Most Cited Articles of Journal of Medicinal Chemistry

TitleYearCitations
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy20045.6K
Molecular properties that influence the oral bioavailability of drug candidates20024K
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes20063.8K
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening20042.9K
Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals20142.5K
The many roles for fluorine in medicinal chemistry20082.5K
A computational procedure for determining energetically favorable binding sites on biologically important macromolecules19852.4K
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays20102.2K
Escape from flatland: increasing saturation as an approach to improving clinical success20092K
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties20002K
Synopsis of some recent tactical application of bioisosteres in drug design20111.8K
Applications of Fluorine in Medicinal Chemistry20151.8K
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)19971.7K
Molecular similarity indices in a comparative analysis (CoMSIA) of drug molecules to correlate and predict their biological activity19941.6K
The PPARs: from orphan receptors to drug discovery20001.6K
The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates20111.5K
MolDock: a new technique for high-accuracy molecular docking20061.5K
The properties of known drugs. 1. Molecular frameworks19961.4K
Novel procedure for modeling ligand/receptor induced fit effects20061.3K
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists19881.3K
A critical assessment of docking programs and scoring functions20061.3K
Organometallic anticancer compounds20111.3K
Rings in drugs20141.2K
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays20041.1K
Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine20031.1K