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Top Articles

1How mitochondria produce reactive oxygen speciesBiochemical Journal20096,321
2Oxygen toxicity, oxygen radicals, transition metals and diseaseBiochemical Journal19844,932
3Caspases: the executioners of apoptosisBiochemical Journal19974,290
4Specificity and mechanism of action of some commonly used protein kinase inhibitorsBiochemical Journal20003,878
5Inositol trisphosphate and diacylglycerol as second messengersBiochemical Journal19843,655
6Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+Biochemical Journal19953,508
7The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassayBiochemical Journal19733,277
8Nitric oxide synthases: structure, function and inhibitionBiochemical Journal20013,123
9A classification of glycosyl hydrolases based on amino acid sequence similaritiesBiochemical Journal19912,901
10Principles of interleukin (IL)-6-type cytokine signalling and its regulationBiochemical Journal20032,784
11Specificity and mechanism of action of some commonly used protein kinase inhibitorsBiochemical Journal20002,718
12Histone deacetylases (HDACs): characterization of the classical HDAC familyBiochemical Journal20032,671
13Nitric oxide synthases in mammalsBiochemical Journal19942,566
14Interleukin-6 and the acute phase responseBiochemical Journal19902,501
15Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosisBiochemical Journal20042,445
16Arginine metabolism: nitric oxide and beyondBiochemical Journal19982,379
17The selectivity of protein kinase inhibitors: a further updateBiochemical Journal20072,287
18Nitric oxide synthases: structure, function and inhibitionBiochemical Journal20012,118
19The mitochondrial permeability transition pore and its role in cell deathBiochemical Journal19992,092
20Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glandsBiochemical Journal19822,080
21Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancerBiochemical Journal19962,020
22Introduction to the human gut microbiotaBiochemical Journal20171,988
23Assessing mitochondrial dysfunction in cellsBiochemical Journal20111,949
24New families in the classification of glycosyl hydrolases based on amino acid sequence similaritiesBiochemical Journal19931,939
25Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayBiochemical Journal19981,895
26Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasisBiochemical Journal19921,827
27Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chainBiochemical Journal20001,762
28Carbohydrate-binding modules: fine-tuning polysaccharide recognitionBiochemical Journal20041,720
29Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsBiochemical Journal19881,707
30Rho GTPases and their effector proteinsBiochemical Journal20001,702
31Extracellular ATP: effects, sources and fateBiochemical Journal19861,636
32Recent advances in the biochemistry of polyamines in eukaryotesBiochemical Journal19861,611
33Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functionsBiochemical Journal19991,541
34The direct linear plot. A new graphical procedure for estimating enzyme kinetic parametersBiochemical Journal19741,526
35Biochemistry and pathology of radical-mediated protein oxidationBiochemical Journal19971,519
36Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingBiochemical Journal20011,516
37The lipocalin protein family: structure and functionBiochemical Journal19961,505
38Sirtuins in mammals: insights into their biological functionBiochemical Journal20071,503
39Free-radical mechanisms in tissue injuryBiochemical Journal19841,489
40The extended protein kinase C superfamilyBiochemical Journal19981,452
41Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamilyBiochemical Journal20011,449
42New photosensitizers for photodynamic therapyBiochemical Journal20161,437
43Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondriaBiochemical Journal19801,397
44The PI3K–PDK1 connection: more than just a road to PKBBiochemical Journal20001,386
45Mechanisms and functions of p38 MAPK signallingBiochemical Journal20101,342
46The specificities of protein kinase inhibitors: an updateBiochemical Journal20031,339
47Updating the sequence-based classification of glycosyl hydrolasesBiochemical Journal19961,293
48Protein kinase C isoenzymes: divergence in signal transduction?Biochemical Journal19931,248
49Autophagy, mitochondria and oxidative stress: cross-talk and redox signallingBiochemical Journal20121,243
50Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetesBiochemical Journal19871,228