| # | Title | Journal | Year | Citations |
|---|
|
| 1 | PHENIX: a comprehensive Python-based system for macromolecular structure solution | Acta Crystallographica Section D: Biological Crystallography | 2010 | 21,358 |
| 2 | Phasercrystallographic software | Journal of Applied Crystallography | 2007 | 18,373 |
| 3 | A human gut microbial gene catalogue established by metagenomic sequencing | Nature | 2010 | 9,658 |
| 4 | Mutations of the BRAF gene in human cancer | Nature | 2002 | 9,550 |
| 5 | MicroRNA expression profiles classify human cancers | Nature | 2005 | 9,031 |
| 6 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 7,201 |
| 7 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,546 |
| 8 | DNA methylation patterns and epigenetic memory | Genes and Development | 2002 | 6,023 |
| 9 | Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy | Nature | 2005 | 5,746 |
| 10 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals | Nature Genetics | 2003 | 5,535 |
| 11 | The free-energy principle: a unified brain theory? | Nature Reviews Neuroscience | 2010 | 5,239 |
| 12 | Roary: rapid large-scale prokaryote pan genome analysis | Bioinformatics | 2015 | 4,422 |
| 13 | GENCODE: The reference human genome annotation for The ENCODE Project | Genome Research | 2012 | 4,320 |
| 14 | PRODRG: a tool for high-throughput crystallography of protein–ligand complexes | Acta Crystallographica Section D: Biological Crystallography | 2004 | 4,313 |
| 15 | miRBase: microRNA sequences, targets and gene nomenclature | Nucleic Acids Research | 2006 | 4,281 |
| 16 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | Lancet, The | 2021 | 4,061 |
| 17 | PHENIX: building new software for automated crystallographic structure determination | Acta Crystallographica Section D: Biological Crystallography | 2002 | 4,047 |
| 18 | Assessment of eating disorders: Interview or self‐report questionnaire? | International Journal of Eating Disorders | 1994 | 4,019 |
| 19 | Genome sequence of the human malaria parasite Plasmodium falciparum | Nature | 2002 | 3,944 |
| 20 | miRBase: tools for microRNA genomics | Nucleic Acids Research | 2007 | 3,894 |
| 21 | Global variation in copy number in the human genome | Nature | 2006 | 3,879 |
| 22 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,455 |
| 23 | Systematic functional analysis of the Caenorhabditis elegans genome using RNAi | Nature | 2003 | 3,401 |
| 24 | The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 | Nucleic Acids Research | 2019 | 3,387 |
| 25 | Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 3,379 |
| 26 | Antibiotic resistance—the need for global solutions | Lancet Infectious Diseases, The | 2013 | 3,343 |
| 27 | Accurate whole human genome sequencing using reversible terminator chemistry | Nature | 2008 | 3,182 |
| 28 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 29 | Merlin—rapid analysis of dense genetic maps using sparse gene flow trees | Nature Genetics | 2002 | 3,121 |
| 30 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) | Nature | 2002 | 2,990 |
| 31 | mRNA-Seq whole-transcriptome analysis of a single cell | Nature Methods | 2009 | 2,900 |
| 32 | Multilocus Sequence Typing for Characterization of Methicillin-Resistant and Methicillin-Susceptible Clones of Staphylococcus aureus | Journal of Clinical Microbiology | 2000 | 2,773 |
| 33 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,758 |
| 34 | Functional and Effective Connectivity: A Review | Brain Connectivity | 2011 | 2,731 |
| 35 | DNA methylation landscapes: provocative insights from epigenomics | Nature Reviews Genetics | 2008 | 2,668 |
| 36 | CpG islands and the regulation of transcription | Genes and Development | 2011 | 2,626 |
| 37 | AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism | Cell Metabolism | 2005 | 2,565 |
| 38 | Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF | Cell | 2004 | 2,537 |
| 39 | Perceptions of epigenetics | Nature | 2007 | 2,509 |
| 40 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,454 |
| 41 | A DNA damage checkpoint response in telomere-initiated senescence | Nature | 2003 | 2,420 |
| 42 | The global distribution of clinical episodes of Plasmodium falciparum malaria | Nature | 2005 | 2,350 |
| 43 | Synaptic, transcriptional and chromatin genes disrupted in autism | Nature | 2014 | 2,344 |
| 44 | Real-space refinement inPHENIXfor cryo-EM and crystallography | Acta Crystallographica Section D: Structural Biology | 2018 | 2,342 |
| 45 | Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics | PLoS Genetics | 2014 | 2,331 |
| 46 | Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range | Diabetes Care | 2019 | 2,328 |
| 47 | Mapping short DNA sequencing reads and calling variants using mapping quality scores | Genome Research | 2008 | 2,289 |
| 48 | Genome sequence, comparative analysis and haplotype structure of the domestic dog | Nature | 2005 | 2,256 |
| 49 | GeneWise and Genomewise | Genome Research | 2004 | 2,227 |
| 50 | Genomic DNA methylation: the mark and its mediators | Trends in Biochemical Sciences | 2006 | 2,220 |
