| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Particle mesh Ewald: AnN⋅log(N) method for Ewald sums in large systems | Journal of Chemical Physics | 1993 | 25,675 |
| 2 | A smooth particle mesh Ewald method | Journal of Chemical Physics | 1995 | 19,008 |
| 3 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 11,297 |
| 4 | Apoptosis: A Review of Programmed Cell Death | Toxicologic Pathology | 2007 | 10,503 |
| 5 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,596 |
| 6 | The Amber biomolecular simulation programs | Journal of Computational Chemistry | 2005 | 8,052 |
| 7 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 7,201 |
| 8 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,546 |
| 9 | Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles | Environmental Health Perspectives | 2005 | 6,536 |
| 10 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,866 |
| 11 | Efficient Global Optimization of Expensive Black-Box Functions | Journal of Global Optimization | 1998 | 5,526 |
| 12 | CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials | BMC Medicine | 2010 | 5,246 |
| 13 | Thin-film thermoelectric devices with high room-temperature figures of merit | Nature | 2001 | 4,938 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 15 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,451 |
| 16 | Structure validation by Cα geometry: ϕ,ψ and Cβ deviation | Proteins: Structure, Function and Bioinformatics | 2003 | 4,212 |
| 17 | Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing | Environmental and Molecular Mutagenesis | 2000 | 4,107 |
| 18 | Estimates of global terrestrial isoprene emissions using MEGAN (Model of Emissions of Gases and Aerosols from Nature) | Atmospheric Chemistry and Physics | 2006 | 3,931 |
| 19 | Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β | Endocrinology | 1998 | 3,781 |
| 20 | Low Health Literacy and Health Outcomes: An Updated Systematic Review | Annals of Internal Medicine | 2011 | 3,593 |
| 21 | Microglia-mediated neurotoxicity: uncovering the molecular mechanisms | Nature Reviews Neuroscience | 2007 | 3,545 |
| 22 | The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants | Journal of Exposure Science and Environmental Epidemiology | 2001 | 3,371 |
| 23 | Identification of the breast cancer susceptibility gene BRCA2 | Nature | 1995 | 3,267 |
| 24 | An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) | Journal of Biological Chemistry | 1995 | 3,180 |
| 25 | The Lancet Commission on pollution and health | Lancet, The | 2018 | 3,027 |
| 26 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites | Gene | 1988 | 2,939 |
| 27 | An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress | Molecular Cell | 2003 | 2,864 |
| 28 | Identification of the haematopoietic stem cell niche and control of the niche size | Nature | 2003 | 2,667 |
| 29 | Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations | Journal of Pain | 2008 | 2,654 |
| 30 | Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs | New England Journal of Medicine | 2005 | 2,618 |
| 31 | Chronic inflammation in the etiology of disease across the life span | Nature Medicine | 2019 | 2,537 |
| 32 | Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses | Endocrine Reviews | 2012 | 2,488 |
| 33 | Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies | American Journal of Human Genetics | 2010 | 2,384 |
| 34 | Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network | Pediatrics | 2010 | 2,326 |
| 35 | Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings | Toxicological Sciences | 2007 | 2,171 |
| 36 | Incidence of Early Loss of Pregnancy | New England Journal of Medicine | 1988 | 2,160 |
| 37 | A Note on Robust Variance Estimation for Cluster‐Correlated Data | Biometrics | 2000 | 2,155 |
| 38 | The State of US Health, 1990-2010 | JAMA - Journal of the American Medical Association | 2013 | 2,130 |
| 39 | Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012 | JAMA - Journal of the American Medical Association | 2015 | 2,127 |
| 40 | Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network | Pediatrics | 2002 | 2,097 |
| 41 | Assessing health status and quality-of-life instruments: attributes and review criteria | Quality of Life Research | 2002 | 2,011 |
| 42 | Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 2,006 |
| 43 | Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial | Lancet, The | 2007 | 1,996 |
| 44 | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation | Cell | 1995 | 1,984 |
| 45 | Review of the Governing Equations, Computational Algorithms, and Other Components of the Models-3 Community Multiscale Air Quality (CMAQ) Modeling System | Applied Mechanics Reviews | 2006 | 1,950 |
| 46 | The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids | Journal of Biological Chemistry | 2003 | 1,934 |
| 47 | Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations | European Journal of Epidemiology | 2016 | 1,932 |
| 48 | Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial | Lancet, The | 2012 | 1,904 |
| 49 | Strategies for mitigating an influenza pandemic | Nature | 2006 | 1,894 |
| 50 | High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence | American Journal of Obstetrics and Gynecology | 2003 | 1,889 |
