The fundamental role of epigenetic events in cancer | Nature Reviews Genetics | 2002 | 4.3K |
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells | Nature | 2002 | 1K |
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status | Nature | 2002 | 962 |
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer | Nature Genetics | 2002 | 766 |
Allelic variation in human gene expression | Science | 2002 | 567 |
Using the transcriptome to annotate the genome | Nature Biotechnology | 2002 | 528 |
A history of prostate cancer treatment | Nature Reviews Cancer | 2002 | 414 |
The role of chromosomal instability in tumor initiation | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 399 |
Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk | Nature Genetics | 2002 | 283 |
Detection of APC mutations in fecal DNA from patients with colorectal tumors | New England Journal of Medicine | 2002 | 267 |
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus | Nature | 2002 | 249 |
Altered methylation patterns in cancer cell genomes: cause or consequence? | Cancer Cell | 2002 | 243 |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer | Cancer Research | 2002 | 229 |
Relapsed ovarian cancer: challenges and management strategies for a chronic disease | Oncologist | 2002 | 227 |
Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes | Molecular and Cellular Biology | 2002 | 206 |
Digital karyotyping | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 191 |
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells | Cancer Research | 2002 | 185 |
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes | Journal of Virology | 2002 | 176 |
Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1 | Cancer Cell | 2002 | 170 |
Prevalence of somatic alterations in the colorectal cancer cell genome | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 163 |
Counting alleles to predict recurrence of early-stage colorectal cancers | Lancet, The | 2002 | 127 |
Targeted inactivation of p53 in human cells does not result in aneuploidy | Cancer Research | 2002 | 123 |
Role and regulation of activator protein-1 in toxicant-induced responses of the lung | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2002 | 118 |
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 108 |
The use of chemotherapy in soft-tissue sarcomas | Oncologist | 2002 | 93 |