| Signal transduction by reactive oxygen species | Journal of Cell Biology | 2011 | 1.5K |
| Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits | PLoS Genetics | 2011 | 629 |
| The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia | Blood | 2011 | 603 |
| Transcriptional activation of lysosomal exocytosis promotes cellular clearance | Developmental Cell | 2011 | 458 |
| Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma | Nature Genetics | 2011 | 415 |
| Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types | Immunity | 2011 | 231 |
| Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins | Molecular Therapy | 2011 | 215 |
| Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity | Blood | 2011 | 179 |
| Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 159 |
| Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells | Journal of Clinical Investigation | 2011 | 144 |
| Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore | Journal of Biological Chemistry | 2011 | 138 |
| Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases | Journal of Biological Chemistry | 2011 | 130 |
| HIV-associated Pneumocystis pneumonia | Proceedings of the American Thoracic Society | 2011 | 118 |
| A genome-wide association study of aging | Neurobiology of Aging | 2011 | 110 |
| The STARBRITE trial: a randomized, pilot study of B-type natriuretic peptide-guided therapy in patients with advanced heart failure | Journal of Cardiac Failure | 2011 | 96 |
| Microscopy in 3D: a biologist's toolbox | Trends in Cell Biology | 2011 | 96 |
| Multiple loci are associated with white blood cell phenotypes | PLoS Genetics | 2011 | 92 |
| AMPK regulates circadian rhythms in a tissue- and isoform-specific manner | PLoS ONE | 2011 | 91 |
| BRCA1 is an essential regulator of heart function and survival following myocardial infarction | Nature Communications | 2011 | 89 |
| Biventricular pacing is superior to right ventricular pacing in bradycardia patients with preserved systolic function: 2-year results of the PACE trial | European Heart Journal | 2011 | 86 |
| Cerivastatin, genetic variants, and the risk of rhabdomyolysis | Pharmacogenetics and Genomics | 2011 | 84 |
| P wave duration is associated with cardiovascular and all-cause mortality outcomes: the National Health and Nutrition Examination Survey | Heart Rhythm | 2011 | 82 |
| Peptide switch is essential for Sirt1 deacetylase activity | Molecular Cell | 2011 | 82 |
| Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression | Blood | 2011 | 82 |
| Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53 | PLoS ONE | 2011 | 80 |
