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| Interpretation of the evidence for the efficacy and safety of statin therapy | Lancet, The | 2016 | 961 |
| Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis | Lancet, The | 2016 | 591 |
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| Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis | JAMA Internal Medicine | 2016 | 388 |
| A critical review of the long-term disability outcomes following hip fracture | BMC Geriatrics | 2016 | 321 |
| Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis | Lancet Diabetes and Endocrinology,the | 2016 | 308 |
| Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function | Nature Communications | 2016 | 295 |
| Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia | Diabetes Care | 2016 | 288 |
| Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke | New England Journal of Medicine | 2016 | 259 |
| Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis | JAMA - Journal of the American Medical Association | 2016 | 258 |
| ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies | JAMA Internal Medicine | 2016 | 238 |
| Prevention of Low Back Pain: A Systematic Review and Meta-analysis | JAMA Internal Medicine | 2016 | 233 |
| The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies | Age and Ageing | 2016 | 215 |
| Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials | PLoS Medicine | 2016 | 212 |
| Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials | American Journal of Respiratory and Critical Care Medicine | 2016 | 192 |
| Consensus on Exercise Reporting Template (CERT): Modified Delphi Study | Physical Therapy | 2016 | 184 |
| Efficacy, Tolerability, and Dose-Dependent Effects of Opioid Analgesics for Low Back Pain: A Systematic Review and Meta-analysis | JAMA Internal Medicine | 2016 | 183 |
| Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies | BMJ, The | 2016 | 160 |
| Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD: A Bayesian Network Meta-analysis of Randomized Clinical Trials | American Journal of Kidney Diseases | 2016 | 159 |
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| Mobile Phone Apps to Improve Medication Adherence: A Systematic Stepwise Process to Identify High-Quality Apps | JMIR MHealth and UHealth | 2016 | 152 |
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