Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 3.2K |
A call for transparent reporting to optimize the predictive value of preclinical research | Nature | 2012 | 795 |
Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis | Lancet, The | 2012 | 695 |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways | Nature Genetics | 2012 | 621 |
IFITM3 restricts the morbidity and mortality associated with influenza | Nature | 2012 | 537 |
Bayesian refinement of association signals for 14 loci in 3 common diseases | Nature Genetics | 2012 | 347 |
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke | Nature Genetics | 2012 | 314 |
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes | Genome Research | 2012 | 305 |
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells | Gastroenterology | 2012 | 294 |
Meta-analysis of genome-wide association studies for personality | Molecular Psychiatry | 2012 | 274 |
The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis | Blood | 2012 | 270 |
1st International consensus guidelines for advanced breast cancer (ABC 1) | Breast | 2012 | 258 |
How do chemotherapeutic agents damage the ovary? | Human Reproduction Update | 2012 | 256 |
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways | Nature Genetics | 2012 | 243 |
A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis | Osteoporosis International | 2012 | 233 |
Incidence, prevention, and management of complications following percutaneous nephrolitholapaxy | European Urology | 2012 | 213 |
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 212 |
Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies | Stroke | 2012 | 198 |
Genetic contributions to stability and change in intelligence from childhood to old age | Nature | 2012 | 189 |
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression | Nucleic Acids Research | 2012 | 189 |
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus | Nature Genetics | 2012 | 186 |
Gout: why is this curable disease so seldom cured? | Annals of the Rheumatic Diseases | 2012 | 182 |
Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors | British Journal of Cancer | 2012 | 165 |
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor | Nature Structural and Molecular Biology | 2012 | 160 |
A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment | Cancer Research | 2012 | 158 |