| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Science | 2002 | 10.5K |
| Cellular response to oxidative stress: signaling for suicide and survival | Journal of Cellular Physiology | 2002 | 1.8K |
| Toxic proteins in neurodegenerative disease | Science | 2002 | 957 |
| Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study | Diabetes | 2002 | 936 |
| Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2002 | 826 |
| Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice | Journal of Neurochemistry | 2002 | 720 |
| Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden | Cancer | 2002 | 708 |
| Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study | Journal of the American Geriatrics Society | 2002 | 609 |
| Differentiation of pluripotent embryonic stem cells into cardiomyocytes | Circulation Research | 2002 | 609 |
| Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study | Annals of Neurology | 2002 | 557 |
| Skeletal muscle strength as a predictor of all-cause mortality in healthy men | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2002 | 555 |
| Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease | Journal of Neuroscience | 2002 | 533 |
| An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage | Journal of Neuroscience | 2002 | 490 |
| Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels | Journal of the American Geriatrics Society | 2002 | 451 |
| Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease | Journal of Neurochemistry | 2002 | 398 |
| Neighborhood environment and loss of physical function in older adults: evidence from the Alameda County Study | American Journal of Epidemiology | 2002 | 385 |
| The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study | Annals of Internal Medicine | 2002 | 368 |
| Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice | Journal of Neurochemistry | 2002 | 362 |
| Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men | Journal of Clinical Endocrinology and Metabolism | 2002 | 357 |
| Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior | Physiological Reviews | 2002 | 352 |
| Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease | Journal of Neurochemistry | 2002 | 317 |
| Personality trait development from age 12 to age 18: Longitudinal, cross-sectional and cross-cultural analyses. | Journal of Personality and Social Psychology | 2002 | 312 |
| Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells | Free Radical Biology and Medicine | 2002 | 308 |
| Biomarkers of caloric restriction may predict longevity in humans | Science | 2002 | 300 |
| Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants | Annals of the New York Academy of Sciences | 2002 | 296 |
