| Oxidants, oxidative stress and the biology of ageing | Nature | 2000 | 6.9K |
| Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2000 | 1.8K |
| A model of neurovisceral integration in emotion regulation and dysregulation | Journal of Affective Disorders | 2000 | 1.7K |
| Current methods in medical image segmentation | Annual Review of Biomedical Engineering | 2000 | 1.4K |
| Apoptosis in neurodegenerative disorders | Nature Reviews Molecular Cell Biology | 2000 | 1.2K |
| Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes | Journal of Experimental Medicine | 2000 | 1.1K |
| Midlife blood pressure and dementia: the Honolulu-Asia aging study | Neurobiology of Aging | 2000 | 640 |
| Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity | Journal of Neuroscience | 2000 | 628 |
| Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study | Journal of the American Geriatrics Society | 2000 | 602 |
| Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth | Journal of Molecular Neuroscience | 2000 | 550 |
| Requirement for ERK activation in cisplatin-induced apoptosis | Journal of Biological Chemistry | 2000 | 525 |
| Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas | Diabetes | 2000 | 504 |
| HuR regulates p21 mRNA stabilization by UV light | Molecular and Cellular Biology | 2000 | 462 |
| Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders | Trends in Neurosciences | 2000 | 421 |
| Muscle strength and body mass index as long-term predictors of mortality in initially healthy men | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2000 | 407 |
| Diabetes and physical disability among older U.S. adults | Diabetes Care | 2000 | 402 |
| One-year age changes in MRI brain volumes in older adults | Cerebral Cortex | 2000 | 383 |
| Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats | Endocrinology | 2000 | 369 |
| Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 357 |
| The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase | Circulation Research | 2000 | 350 |
| Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest | EMBO Reports | 2000 | 343 |
| Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study | Arteriosclerosis, Thrombosis, and Vascular Biology | 2000 | 318 |
| Aging and cancer in America. Demographic and epidemiologic perspectives | Hematology/Oncology Clinics of North America | 2000 | 317 |
| Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer | Cancer Research | 2000 | 306 |
| Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2000 | 305 |
