| Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression | Cell Reports | 2017 | 749 |
| Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug | Nature Medicine | 2017 | 732 |
| Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 508 |
| Obesity | Nature Reviews Disease Primers | 2017 | 464 |
| Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials | Annals of Oncology | 2017 | 454 |
| The global problem of antifungal resistance: prevalence, mechanisms, and management | Lancet Infectious Diseases, The | 2017 | 403 |
| The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study | Lancet, The | 2017 | 350 |
| Nursing skill mix in European hospitals: cross-sectional study of the association with mortality, patient ratings, and quality of care | BMJ Quality and Safety | 2017 | 306 |
| Relationship between depression and frailty in older adults: A systematic review and meta-analysis | Ageing Research Reviews | 2017 | 262 |
| CD69: from activation marker to metabolic gatekeeper | European Journal of Immunology | 2017 | 261 |
| Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation | Free Radical Biology and Medicine | 2017 | 239 |
| Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 237 |
| Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study | JAMA Oncology | 2017 | 236 |
| Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases | Nutrients | 2017 | 184 |
| Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation | Nutrition Reviews | 2017 | 183 |
| Microplastic ingestion by Mullus surmuletus Linnaeus, 1758 fish and its potential for causing oxidative stress | Environmental Research | 2017 | 178 |
| Human papillomavirus-related oropharyngeal cancer | Annals of Oncology | 2017 | 168 |
| The long noncoding RNA controls cardiac fibrosis and remodeling | Science Translational Medicine | 2017 | 167 |
| An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence | Hormone Research in Paediatrics | 2017 | 166 |
| Force loading explains spatial sensing of ligands by cells | Nature | 2017 | 163 |
| Ultra-Processed Food Consumption and the Incidence of Hypertension in a Mediterranean Cohort: The Seguimiento Universidad de Navarra Project | American Journal of Hypertension | 2017 | 163 |
| Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea) | Circulation | 2017 | 161 |
| Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging | Trends in Molecular Medicine | 2017 | 159 |
| HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism | Nature Communications | 2017 | 158 |
| Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer | JAMA Oncology | 2017 | 152 |
