| High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes | Journal of Experimental Medicine | 2000 | 1.2K |
| Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 654 |
| Effect of a surgical training programme on outcome of rectal cancer in the County of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project | Lancet, The | 2000 | 638 |
| Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry | Circulation | 2000 | 598 |
| Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients | Transplantation | 2000 | 444 |
| Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer: a randomised trial. Scandinavian Breast Group 9401 study | Lancet, The | 2000 | 374 |
| Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes | Nature Genetics | 2000 | 371 |
| Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons | Nature Neuroscience | 2000 | 335 |
| Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 323 |
| Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 320 |
| Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. European Orlistat Obesity Study Group | Obesity | 2000 | 319 |
| Human papillomavirus (HPV) DNA in tonsillar cancer: Clinical correlates, risk of relapse, and survival | International Journal of Cancer | 2000 | 314 |
| Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients | Diabetes | 2000 | 293 |
| Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study | Journal of the National Cancer Institute | 2000 | 292 |
| Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial | New England Journal of Medicine | 2000 | 282 |
| Insulin action and insulin resistance in human skeletal muscle | Diabetologia | 2000 | 280 |
| Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells | Journal of Neuroscience | 2000 | 278 |
| Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis | Journal of Allergy and Clinical Immunology | 2000 | 275 |
| Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 271 |
| Health-related quality of life measured by the EORTC QLQ-C30--reference values from a large sample of Swedish population | Acta Oncológica | 2000 | 270 |
| Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes | Upsala Journal of Medical Sciences | 2000 | 268 |
| Effect of intravenous nimodipine on blood pressure and outcome after acute stroke | Stroke | 2000 | 261 |
| Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays | Nature Biotechnology | 2000 | 259 |
| Impaired endothelial function and increased carotid stiffness in 9-year-old children with low birthweight | Circulation | 2000 | 245 |
| Suicide prevention--a medical breakthrough? | Acta Psychiatrica Scandinavica | 2000 | 242 |
