| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Particle mesh Ewald: AnN⋅log(N) method for Ewald sums in large systems | Journal of Chemical Physics | 1993 | 25,675 |
| 2 | A smooth particle mesh Ewald method | Journal of Chemical Physics | 1995 | 19,008 |
| 3 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 11,297 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,596 |
| 5 | The Amber biomolecular simulation programs | Journal of Computational Chemistry | 2005 | 8,052 |
| 6 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 7,201 |
| 7 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,546 |
| 8 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,866 |
| 9 | Mutational heterogeneity in cancer and the search for new cancer-associated genes | Nature | 2013 | 4,897 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 11 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,451 |
| 12 | Microglia-mediated neurotoxicity: uncovering the molecular mechanisms | Nature Reviews Neuroscience | 2007 | 3,545 |
| 13 | Identification of the breast cancer susceptibility gene BRCA2 | Nature | 1995 | 3,267 |
| 14 | The Lancet Commission on pollution and health | Lancet, The | 2018 | 3,027 |
| 15 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites | Gene | 1988 | 2,939 |
| 16 | An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress | Molecular Cell | 2003 | 2,864 |
| 17 | Identification of the haematopoietic stem cell niche and control of the niche size | Nature | 2003 | 2,667 |
| 18 | Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs | New England Journal of Medicine | 2005 | 2,618 |
| 19 | Chronic inflammation in the etiology of disease across the life span | Nature Medicine | 2019 | 2,537 |
| 20 | Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses | Endocrine Reviews | 2012 | 2,488 |
| 21 | The repertoire of mutational signatures in human cancer | Nature | 2020 | 2,356 |
| 22 | Incidence of Early Loss of Pregnancy | New England Journal of Medicine | 1988 | 2,160 |
| 23 | The State of US Health, 1990-2010 | JAMA - Journal of the American Medical Association | 2013 | 2,130 |
| 24 | High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence | American Journal of Obstetrics and Gynecology | 2003 | 1,889 |
| 25 | Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification | Toxicologic Pathology | 2002 | 1,832 |
| 26 | Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration | Glia | 2007 | 1,830 |
| 27 | Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer | Cell | 2017 | 1,827 |
| 28 | Genome-wide association study reveals genetic risk underlying Parkinson's disease | Nature Genetics | 2009 | 1,783 |
| 29 | Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us? | Endocrine Reviews | 1999 | 1,772 |
| 30 | Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,728 |
| 31 | Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease | Nature Genetics | 2014 | 1,721 |
| 32 | Rates of Spontaneous Mutation | Genetics | 1998 | 1,686 |
| 33 | A Test of Neutral Molecular Evolution Based on Nucleotide Data | Genetics | 1987 | 1,670 |
| 34 | Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,661 |
| 35 | EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals | Endocrine Reviews | 2015 | 1,621 |
| 36 | Generation and reproductive phenotypes of mice lacking estrogen receptor β | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,548 |
| 37 | STATISTICAL PROPERTIES OF THE NUMBER OF RECOMBINATION EVENTS IN THE HISTORY OF A SAMPLE OF DNA SEQUENCES | Genetics | 1985 | 1,543 |
| 38 | Capacitative calcium entry revisited | Cell Calcium | 1990 | 1,475 |
| 39 | Opportunities and obstacles for deep learning in biology and medicine | Journal of the Royal Society Interface | 2018 | 1,403 |
| 40 | Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism | Progress in Neurobiology | 2005 | 1,369 |
| 41 | Control of microglial neurotoxicity by the fractalkine receptor | Nature Neuroscience | 2006 | 1,356 |
| 42 | The investigation of linkage between a quantitative trait and a marker locus | Behavior Genetics | 1972 | 1,348 |
| 43 | Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice | Cell | 1997 | 1,322 |
| 44 | ART: a next-generation sequencing read simulator | Bioinformatics | 2012 | 1,303 |
| 45 | Molecular definitions of autophagy and related processes | EMBO Journal | 2017 | 1,293 |
| 46 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,263 |
| 47 | Capturing and profiling adult hair follicle stem cells | Nature Biotechnology | 2004 | 1,211 |
| 48 | DNA MISMATCH REPAIR | Annual Review of Biochemistry | 2005 | 1,201 |
| 49 | Immune regulation by glucocorticoids | Nature Reviews Immunology | 2017 | 1,199 |
| 50 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,182 |
